SynthesisPloS one2012
Erectile dysfunction and cardiovascular events in diabetic men: a meta-analysis of observational studies.
Synthesis in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- The global burden of erectile dysfunction and its associated risk factors in diabetic patients: an umbrella reviews.BMC public health · 2024Pooled it
- People smoke for nicotine, but lose sexual and reproductive health for tar: a narrative review on the effect of cigarette smoking on male sexuality and reproduction.Journal of endocrinological investigation · 2020Pooled it
- Long-term high-dose L-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial.Journal of endocrinological investigation · 2022Trial
- Prevalence of Erectile Dysfunction in Malagasy Patients With Diabetes Mellitus and Its Associations With Atherosclerotic Cardiovascular Diseases: A Cross-Sectional Study.Endocrinology, diabetes & metabolism · 2025Article
- Patients phenotypes and cardiovascular risk in type 2 diabetes: the Jackson Heart Study.Cardiovascular diabetology · 2022Article
- Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs.Nature reviews. Cardiology · 2022Review
- Male and female sexual dysfunction in diabetic subjects: Focus on new antihyperglycemic drugs.Reviews in endocrine & metabolic disorders · 2020Review
- Erectile dysfunction severity as a predictor of left main and/or three-vessel disease in acute coronary syndrome patients.Indian heart journal · 2018Article
- Obesity and Sexual Functioning.Current obesity reports · 2018Review
- Relationship between erectile dysfunction and the neutrophil to lymphocyte and platelet to lymphocyte ratios.International journal of impotence research · 2018Article
- Article
- Activation of the NGF/TrkA signaling pathway attenuates diabetic erectile dysfunction.Oncotarget · 2017Article
- Sexual dysfunction among diabetics and its impact on the SQoL of their partners.International journal of impotence research · 2017Article
- Association between coronary heart disease and erectile dysfunction in Chinese Han population.Oncotarget · 2017Article
- Cardiovascular risk assessment in patients with diabetes.Diabetology & metabolic syndrome · 2017Review
- Relation Between Erectile Dysfunction and Silent Myocardial Ischemia in Diabetic Patients: A Multidetector Computed Tomographic Coronary Angiographic Study.Sexual medicine · 2016Article
- Erectile dysfunction in patients with plaque psoriasis: the relation of depression and cardiovascular factors.International journal of impotence research · 2016Observational
- Erectile dysfunction.Nature reviews. Disease primers · 2016Review
- Sexual Dysfunction in Type 2 Diabetes at Diagnosis: Progression over Time and Drug and Non-Drug Correlated Factors.PloS one · 2016Observational
- Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?World journal of diabetes · 2014 · on this mapReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have shown that erectile dysfunction (ED) influences the risk of cardiovascular events (CV events). However, a meta-analysis of the overall risk of CV events associated with ED in patients with diabetes has not been performed. METHODOLOGY/PRINCIPAL
findingsWe searched MEDLINE and the Cochrane Library for pertinent articles (including references) published between 1951 and April 22, 2012. English language reports of original observational cohort studies and cross-sectional studies were included. Pooled effect estimates were obtained by random effects meta-analysis. A total of 3,791 CV events were reported in 3 cohort studies and 9 cross-sectional studies (covering 22,586 subjects). Across the cohort studies, the overall odds ratio (OR) of diabetic men with ED versus those without ED was 1.74 (95% confidence interval [CI]: 1.34-2.27; P<0.001) for CV events and 1.72 (95% CI: 1.5-1.98; P<0.001) for coronary heart disease (CHD). The funnel plot, Begg's test, and Egger's test did not show evidence of publication bias (all P>0.05). Moreover, meta-regression analysis found no relationship between the method used to assess ED (questionnaire or interview), mean age, mean hemoglobin A(1c), mean body mass index, or mean duration of diabetes and the risk of CV events or CHD. In the cross-sectional studies, the OR of diabetic men with ED versus those without ED was 3.39 (95% CI: 2.58-4.44; P<0.001) for CV events (N = 9), 3.43 (95% CI: 2.46-4.77; P<0.001) for CHD (N = 7), and 2.63 (95% CI: 1.41-4.91; P = 0.002) for peripheral vascular disease (N = 5). CONCLUSION/SIGNIFICANCE: ED was associated with an increased risk of CV events in diabetic patients. Prevention and early detection of cardiovascular disease are important in the management of diabetes, especially in view of the rapid increase in its prevalence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.