ArticleJournal of clinical biochemistry and nutrition2012
Proton pump inhibitor-amoxicillin-clarithromycin versus proton pump inhibitor-amoxicillin-metronidazole as first-line Helicobacter pylori eradication therapy.
Article in Journal of clinical biochemistry and nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication: a prospective randomized study.European journal of clinical pharmacology · 2013Trial
- High-dose amoxicillin and pantoprazole regimen forPrzeglad gastroenterologiczny · 2025Article
- Assessing the efficacy of cinnamon compounds against H. pylori through molecular docking, MD Simulations and ADMET analyses.PloS one · 2024Article
- Anti-Helicobacter pylori Activity of Isocoumarin Paepalantine: Morphological and Molecular Docking Analysis.Molecules (Basel, Switzerland) · 2017Article
- Effects of patient age and choice of antisecretory agent on success of eradication therapy forJournal of clinical biochemistry and nutrition · 2017Article
- Esomeprazole- or rabeprazole-based triple therapy eradicatedJournal of clinical biochemistry and nutrition · 2016Article
- Helicobacter pylori in gastric carcinogenesis.World journal of gastrointestinal oncology · 2015Review
- Antibiotic treatment for Helicobacter pylori: Is the end coming?World journal of gastrointestinal pharmacology and therapeutics · 2015Review
- Article
- Current Paradigm and Future Directions for Treatment of Helicobacter pylori Infection.Current treatment options in gastroenterology · 2014Article
- Approach to Helicobacter pylori infection in geriatric population.World journal of gastrointestinal pharmacology and therapeutics · 2014Review
- Detection of genotypic clarithromycin-resistant Helicobacter pylori by string tests.World journal of gastroenterology · 2014Article
- Improvement of reflux symptom related quality of life after Helicobacter pylori eradication therapy.Journal of clinical biochemistry and nutrition · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to compare the efficacy and tolerability of the first-line Helicobacter pylori (H. pylori) eradication regimen composed of proton pump inhibitor, clarithromycin, and amoxicillin, with those of a regimen composed of proton pump inhibitor, metronidazole, and amoxicillin. Data of patients, who were administered the first-line H. pylori eradication regimen at Tokyo Medical Center between 2008 and 2011, were reviewed. All patients had H. pylori gastritis without peptic ulcer disease. The 7-day triple regimen composed of lansoprazole, clarithromycin, and amoxicillin was administered to 55 patients, and that composed of omeprazole, metronidazole, and amoxicillin was administered to 55 patients. Intention-to-treat and per-protocol eradication rates were 74.5 and 80.4%, respectively, for the regimen of lansoprazole, clarithromycin, and amoxicillin, whereas the corresponding rates were 96.4 and 100%, respectively, for the regimen of omeprazole, metronidazole, and amoxicillin. In conclusion, first-line H. pylori eradication therapy composed of omeprazole, metronidazole, and amoxicillin was significantly more effective than that composed of lansoprazole, clarithromycin, and amoxicillin, without differences in tolerability.
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