ArticleJournal of membrane science2012
Immobilized Carbonic Anhydrase on Hollow Fiber Membranes Accelerates CO(2) Removal from Blood.
Article in Journal of membrane science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 79 citations in OpenAlex.
- Immobilized neuroglobin scavenges carbon monoxide from circulating carboxyhemoglobin.bioRxiv : the preprint server for biology · 2026Article
- High-Performance Polyolefin Material: Synthesis, Properties, and Application of Poly(4-Methyl-1-pentene).International journal of molecular sciences · 2025Review
- Improving the hemocompatibility of a porohyperelastic layered vascular graft using luminal reversal microflows.Journal of the mechanical behavior of biomedical materials · 2024Article
- Developing Enzyme Immobilization with Fibrous Membranes: Longevity and Characterization Considerations.Membranes · 2023Review
- Biocatalytic Membranes for Carbon Capture and Utilization.Membranes · 2023Review
- Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters.International journal of environmental research and public health · 2021Article
- Research and Development Journey and Future Trends of Hollow Fiber Membranes for Purification Applications (1970-2020): A Bibliometric Analysis.Membranes · 2021Article
- Physiological Basis of Extracorporeal Membrane Oxygenation and Extracorporeal Carbon Dioxide Removal in Respiratory Failure.Membranes · 2021Review
- Suitable COBioengineering (Basel, Switzerland) · 2021Article
- Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO).Advanced composites and hybrid materials · 2021Review
- Development of zwitterionic sulfobetaine block copolymer conjugation strategies for reduced platelet deposition in respiratory assist devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2018Article
- Time course of red blood cell intracellular pH recovery following short-circuiting in relation to venous transit times in rainbow trout, Oncorhynchus mykiss.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Surface modification of polypropylene for enhanced layer-by-layer deposition of polyelectrolytes.Journal of biomedical materials research. Part A · 2018Article
- Extracorporeal carbon dioxide removal (ECCOJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2017Review
- Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood.Acta biomaterialia · 2015Article
- Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs.Journal of materials science. Materials in medicine · 2015Article
- Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Effect of impeller design and spacing on gas exchange in a percutaneous respiratory assist catheter.Artificial organs · 2014Article
- Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications.Journal of materials science. Materials in medicine · 2013Article
- Carbonic anhydrases and their biotechnological applications.Biomolecules · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Current artificial lungs and respiratory assist devices designed for carbon dioxide removal (CO(2)R) are limited in their efficiency due to the relatively small partial pressure difference across gas exchange membranes. To offset this underlying diffusional challenge, bioactive hollow fiber membranes (HFMs) increase the carbon dioxide diffusional gradient through the immobilized enzyme carbonic anhydrase (CA), which converts bicarbonate to CO(2) directly at the HFM surface. In this study, we tested the impact of CA-immobilization on HFM CO(2) removal efficiency and thromboresistance in blood. Fiber surface modification with radio frequency glow discharge (RFGD) introduced hydroxyl groups, which were activated by 1M CNBr while 1.5M TEA was added drop wise over the activation time course, then incubation with a CA solution covalently linked the enzyme to the surface. The bioactive HFMs were then potted in a model gas exchange device (0.0084 m(2)) and tested in a recirculation loop with a CO(2) inlet of 50mmHg under steady blood flow. Using an esterase activity assay, CNBr chemistry with TEA resulted in 0.99U of enzyme activity, a 3.3 fold increase in immobilized CA activity compared to our previous method. These bioactive HFMs demonstrated 108 ml/min/m(2) CO(2) removal rate, marking a 36% increase compared to unmodified HFMs (p < 0.001). Thromboresistance of CA-modified HFMs was assessed in terms of adherent platelets on surfaces by using lactate dehydrogenase (LDH) assay as well as scanning electron microscopy (SEM) analysis. Results indicated HFMs with CA modification had 95% less platelet deposition compared to unmodified HFM (p < 0.01). Overall these findings revealed increased CO(2) removal can be realized through bioactive HFMs, enabling a next generation of more efficient CO(2) removal intravascular and paracorporeal respiratory assist devices.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.