ArticleBioinformatics (Oxford, England)2012
Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration.
Article in Bioinformatics (Oxford, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Article
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- Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration.PLoS computational biology · 2021Article
- A Near-Optimal Control Method for Stochastic Boolean Networks.Letters in biomathematics · 2020Article
- Controlling large Boolean networks with single-step perturbations.Bioinformatics (Oxford, England) · 2019Article
- BIOPYDB: A Dynamic Human Cell Specific Biochemical Pathway Database with Advanced Computational Analyses Platform.Journal of integrative bioinformatics · 2018Article
- Boolean network modeling in systems pharmacology.Journal of pharmacokinetics and pharmacodynamics · 2018Review
- The Impact of the Epithelial-Mesenchymal Transition Regulator Hepatocyte Growth Factor Receptor/Met on Skin Immunity by Modulating Langerhans Cell Migration.Frontiers in immunology · 2018Review
- Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways.Frontiers in physiology · 2018Article
- Specific role of RhoC in tumor invasion and metastasis.Oncotarget · 2017Article
- Understanding the mTOR signaling pathway via mathematical modeling.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing.Journal of visualized experiments : JoVE · 2016Article
- A MAPK-Driven Feedback Loop Suppresses Rac Activity to Promote RhoA-Driven Cancer Cell Invasion.PLoS computational biology · 2016Article
- Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation.Frontiers in genetics · 2016Article
- Identifying robust communities and multi-community nodes by combining top-down and bottom-up approaches to clustering.Scientific reports · 2015Article
- Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.Scientific reports · 2015Article
- Discovery of Drug Synergies in Gastric Cancer Cells Predicted by Logical Modeling.PLoS computational biology · 2015Article
- HGF/Met-Signaling Contributes to Immune Regulation by Modulating Tolerogenic and Motogenic Properties of Dendritic Cells.Biomedicines · 2015Review
- Robustness and evolvability of the human signaling network.PLoS computational biology · 2014Article
- Steady state analysis of Boolean molecular network models via model reduction and computational algebra.BMC bioinformatics · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
motivationCell migration is a complex process that is controlled through the time-sequential feedback regulation of protein signalling and gene regulation. Based on prior knowledge and own experimental data, we developed a large-scale dynamic network describing the onset and maintenance of hepatocyte growth factor-induced migration of primary human keratinocytes. We applied Boolean logic to capture the qualitative behaviour as well as short-and long-term dynamics of the complex signalling network involved in this process, comprising protein signalling, gene regulation and autocrine feedback.
resultsA Boolean model has been compiled from time-resolved transcriptome data and literature mining, incorporating the main pathways involved in migration from initial stimulation to phenotype progress. Steady-state analysis under different inhibition and stimulation conditions of known key molecules reproduces existing data and predicts novel interactions based on our own experiments. Model simulations highlight for the first time the necessity of a temporal sequence of initial, transient MET receptor (met proto-oncogene, hepatocyte growth factor receptor) and subsequent, continuous epidermal growth factor/integrin signalling to trigger and sustain migration by autocrine signalling that is integrated through the Focal adhesion kinase protein. We predicted in silico and verified in vitro that long-term cell migration is stopped if any of the two feedback loops are inhibited. AVAILABILITY: The network file for analysis with the R BoolNet library is available in the Supplementary Information. CONTACT: melanie.boerries@frias.uni-freiburg.de or hauke.busch@frias.uni-freiburg.de SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.