ArticleEukaryotic cell2013
Overexpression of a novel biotrophy-specific Colletotrichum truncatum effector, CtNUDIX, in hemibiotrophic fungal phytopathogens causes incompatibility with their host plants.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Conventional and new-breeding technologies for improving disease resistance in lentil (Frontiers in plant science · 2022Pooled it
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- CaSun1, a SUN family protein, governs the pathogenicity ofHorticulture research · 2025Article
- A perspective on varied fungal virulence factors causing infection in host plants.Molecular biology reports · 2024Review
- Histological and transcriptomic insights into the interaction between grapevine andFrontiers in plant science · 2024Article
- The Hidden Truths of Fungal Virulence and Adaptation on Hosts: Unraveling the Conditional Dispensability of Minichromosomes in the HemibiotrophicInternational journal of molecular sciences · 2023Review
- The nuclear effector MoHTR3 of Magnaporthe oryzae modulates host defence signalling in the biotrophic stage of rice infection.Molecular plant pathology · 2023Article
- Pectate Lyase Genes Abundantly Expressed During the Infection Regulate Morphological Development ofmSphere · 2023Article
- Identification of candidate genes associated with resistance against race 0 of Colletotrichum lentis in Lens ervoides.Scientific reports · 2022Article
- Characterization of infected process and primary mechanism in rice Acuce defense against rice blast fungus, Magnaporthe oryzae.Plant molecular biology · 2022Article
- Host genotype controls ecological change in the leaf fungal microbiome.PLoS biology · 2022Article
- Effector Sntf2 Interacted with Chloroplast-Related Protein Mdycf39 Promoting the Colonization ofInternational journal of molecular sciences · 2022Article
- A putative effector of the rubber-tree powdery mildew fungus has elicitor activity that can trigger plant immunity.Planta · 2022Article
- Proteinaceous Effector Discovery and Characterization in Plant PathogenicFrontiers in microbiology · 2022Review
- Identification and Comparison ofPathogens (Basel, Switzerland) · 2021Article
- Soybean anthracnose caused by Colletotrichum species: Current status and future prospects.Molecular plant pathology · 2021Review
- Magnaporthe oryzae systemic defense trigger 1 (MoSDT1)-mediated metabolites regulate defense response in Rice.BMC plant biology · 2021Article
- Effectors of Plant Necrotrophic Fungi.Frontiers in plant science · 2021Review
- Deciphering the Infectious Process ofMicroorganisms · 2020Article
- A novel effector CfEC92 of Colletotrichum fructicola contributes to glomerella leaf spot virulence by suppressing plant defences at the early infection phase.Molecular plant pathology · 2020Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hemibiotrophic fungus Colletotrichum truncatum causes anthracnose disease on lentils and a few other grain legumes. It shows initial symptomless intracellular growth, where colonized host cells remain viable (biotrophy), and then switches to necrotrophic growth, killing the colonized host plant tissues. Here, we report a novel effector gene, CtNUDIX, from C. truncatum that is exclusively expressed during the late biotrophic phase (before the switch to necrotrophy) and elicits a hypersensitive response (HR)-like cell death in tobacco leaves transiently expressing the effector. CtNUDIX homologs, which contain a signal peptide and a Nudix hydrolase domain, may be unique to hemibiotrophic fungal and fungus-like plant pathogens. CtNUDIX lacking a signal peptide or a Nudix motif failed to induce cell death in tobacco. Expression of CtNUDIX:eGFP in tobacco suggested that the fusion protein might act on the host cell plasma membrane. Overexpression of CtNUDIX in C. truncatum and the rice blast pathogen, Magnaporthe oryzae, resulted in incompatibility with the hosts lentil and barley, respectively, by causing an HR-like response in infected host cells associated with the biotrophic invasive hyphae. These results suggest that C. truncatum and possibly M. oryzae elicit cell death to signal the transition from biotrophy to necrotrophy.
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