ArticleJournal of biomedical materials research. Part A2013
A novel suture-based method for efficient transplantation of stem cells.
Article in Journal of biomedical materials research. Part A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Stem cell therapy applied for digestive anastomosis: Current state and future perspectives.World journal of stem cells · 2022Article
- Smart surgical sutures using soft artificial muscles.Scientific reports · 2021Article
- The effect of fibrin formulation on cell migration in an in vitro tendon repair model.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2021Article
- Development of a Contractile Cardiac Fiber From Pluripotent Stem Cell Derived Cardiomyocytes.Frontiers in cardiovascular medicine · 2018Article
- Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds.Biomaterials · 2017Article
- Nanofibrillar cellulose-alginate hydrogel coated surgical sutures as cell-carrier systems.PloS one · 2017Article
- Delivering stem cells to the healthy heart on biological sutures: effects on regional mechanical function.Journal of tissue engineering and regenerative medicine · 2017Article
- Optimizing a spontaneously contracting heart tissue patch with rat neonatal cardiac cells on fibrin gel.Journal of tissue engineering and regenerative medicine · 2017Article
- Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice.American journal of translational research · 2017Article
- Aprotinin extends mechanical integrity time of cell-seeded fibrin sutures.Journal of biomedical materials research. Part A · 2016Article
- Heparinized collagen sutures for sustained delivery of PDGF-BB: Delivery profile and effects on tendon-derived cells In-Vitro.Acta biomaterialia · 2016Article
- Isolation and culture of primary rat adipose derived stem cells using porous biopolymer microcarriers.Tissue engineering and regenerative medicine · 2016Article
- Designing Biopolymer Microthreads for Tissue Engineering and Regenerative Medicine.Current stem cell reports · 2016Article
- A novel platelet lysate hydrogel for endothelial cell and mesenchymal stem cell-directed neovascularization.Acta biomaterialia · 2016Article
- Functional Effects of Delivering Human Mesenchymal Stem Cell-Seeded Biological Sutures to an Infarcted Heart.BioResearch open access · 2016Article
- Effect of Fibrin Formulation on Initial Strength of Tendon Repair and Migration of Bone Marrow Stromal Cells in Vitro.The Journal of bone and joint surgery. American volume · 2015Article
- Static axial stretching enhances the mechanical properties and cellular responses of fibrin microthreads.Acta biomaterialia · 2014Article
- Article
- Heart Regeneration with Embryonic Cardiac Progenitor Cells and Cardiac Tissue Engineering.Journal of stem cell and transplantation biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Advances in regenerative medicine have improved the potential of using cellular therapy for treating several diseases. However, the effectiveness of new cellular therapies is largely limited by low cell engraftment and inadequate localization. To improve on these limitations, we developed a novel delivery mechanism using cell-seeded biological sutures. We demonstrate the ability of cell-seeded biological sutures to efficiently implant human mesenchymal stem cells (hMSCs) to specific regions within the beating heart; a tissue known to have low cell retention and engraftment shortly after delivery. Cell-seeded biological sutures were developed by bundling discrete microthreads extruded from extracellular matrix proteins, attaching a surgical needle to the bundle and seeding the bundle with hMSCs. During cell preparation, hMSCs were loaded with quantum dot nanoparticles for cell tracking within the myocardium. Each biological suture contained an average of 5903 ± 1966 hMSCs/cm suture length. Delivery efficiency was evaluated by comparing cell-seeded biological suture implantation with intramyocardial (IM) cell injections (10,000 hMSCs in 35 μL) into the left ventricle of normal, noninfarcted rat hearts after 1 h. Delivery efficiency of hMSCs by biological sutures (63.6 ± 10.6%) was significantly higher than IM injection (11.8 ± 6.2%; p < 0.05). Cell-tracking analysis indicated suture-delivered hMSCs were found throughout the thickness of the ventricular myocardium: along the entire length of the biological suture track, localizing closely with native myocardium. These results suggest cell-seeded biological sutures can deliver cells to the heart more efficiently than conventional methods, demonstrating an effective delivery method for implanting cells in soft tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.