ArticleChembiochem : a European journal of chemical biology2012
Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.
Article in Chembiochem : a European journal of chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
- Targeting lysine acetylation readers and writers.Nature reviews. Drug discovery · 2025Review
- Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals.Chemical reviews · 2024Review
- Alzheimer's Disease-Related Epigenetic Changes: Novel Therapeutic Targets.Molecular neurobiology · 2024Review
- Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.Nature chemical biology · 2023Article
- Serine starvation silences estrogen receptor signaling through histone hypoacetylation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Chemoenzymatic Semisynthesis of Proteins.Chemical reviews · 2020Review
- MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.Cancer research · 2019Article
- Histone/protein deacetylase inhibitor therapy for enhancement of Foxp3+ T-regulatory cell function posttransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Review
- Chemical Control of a CRISPR-Cas9 Acetyltransferase.ACS chemical biology · 2018Article
- CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.Molecular cell · 2017Article
- Phenylpyrrolidine structural mimics of pirfenidone lacking antifibrotic activity: A new tool for mechanism of action studies.European journal of pharmacology · 2017Article
- Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112.Biochemistry · 2016Article
- Global Profiling of Acetyltransferase Feedback Regulation.Journal of the American Chemical Society · 2016Article
- Protein lysine acetylation by p300/CBP.Chemical reviews · 2015Review
- PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.Journal of medicinal chemistry · 2015Article
- Defining the orphan functions of lysine acetyltransferases.ACS chemical biology · 2015Review
- Monitoring of post-translational modification dynamics with genetically encoded fluorescent reporters.Biopolymers · 2014Review
- Metabolic mechanisms of epigenetic regulation.ACS chemical biology · 2013Review
- Learning tasks as a possible treatment for DNA lesions induced by oxidative stress in hippocampal neurons.Neural regeneration research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
Histone acetyltransferase enzymes (HATs) are important therapeutic targets, but there are few cell-based assays available for evaluating the pharmacodynamics of HAT inhibitors. Here we present the application of a FRET-based reporter, Histac, in live-cell studies of p300/CBP HAT inhibition, by both genetic and pharmacologic disruption. shRNA knockdown of p300/CBP led to increased Histac FRET, thus suggesting a role for p300/CBP in the acetylation of the histone H4 tail. Additionally, we describe a new p300/CBP HAT inhibitor, C107, and show that it can also increase cellular Histac FRET. Taken together, these studies provide a live-cell strategy for identifying and evaluating p300/CBP inhibitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.