ArticleChembiochem : a European journal of chemical biology2012
The α-ketoglutarate/Fe(II)-dependent dioxygenase VldW is responsible for the formation of validamycin B.
Article in Chembiochem : a European journal of chemical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Sponge-Derived Streptomyces variabilis Extract Modulates Host Immune Gene Expression and Improves Survival in Caenorhabditis elegans During Vibrio parahaemolyticus Infection.Current microbiology · 2026Article
- A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)-an enzyme with a broad range of substrates.The FEBS journal · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
From A to B: Through detailed biochemical investigations, we discovered that VldW, an α-ketoglutarate/Fe(II)-dependent dioxygenase, regioselectively hydroxylates validamycin A to validamycin B. The results provide insights into the biosynthesis of hydroxylated validamycins and could be used to control the metabolic outcomes of the validamycin pathway.
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Registered trials
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