ArticleDiabetes care2013
White blood cells count and incidence of type 2 diabetes in young men.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 146 citations in OpenAlex.
- Key biomarkers in type 2 diabetes patients: A systematic review.Diabetes, obesity & metabolism · 2025Pooled it
- Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.Nature medicine · 2019Trial
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- Association of leukocyte count with death in people with HIV: A longitudinal study over 24 years.PloS one · 2026Article
- Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women.Endocrine connections · 2026Article
- Prevalence and clinical correlates of diabetes in hospitalized heart failure patients: a retrospective study.Frontiers in endocrinology · 2026Article
- Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults.Frontiers in medicine · 2026Article
- Association Between Neutrophil-to-HDL Ratio and Full-Spectrum Dysglycemia: Insights from a Large Middle Eastern Population Study.Healthcare (Basel, Switzerland) · 2025Article
- Leukocyte count and new-onset diabetes mellitus in people with HIV: A longitudinal study.HIV medicine · 2025Article
- Impact of a Major Earthquake on Glycemic Control in Adults with Type 2 Diabetes: A Retrospective Cohort Study from Türkiye.Diagnostics (Basel, Switzerland) · 2025Article
- Body composition markers are more strongly associated with type 2 diabetes than inflammatory markers-Results from the study of health in Pomerania.European journal of clinical investigation · 2025Article
- Correlation between key indicators of continuous glucose monitoring and the risk of diabetic foot.World journal of diabetes · 2025Article
- Mendelian randomization study highlights the role of hematological traits on Type-2 diabetes mellitus in African ancestry individuals.Frontiers in pharmacology · 2025Article
- Article
- Comparative Evaluation of Inflammatory Markers NLR, PLR, IL-6, and HbA1c in Type 2 Diabetes Mellitus: A Hospital Based Study.Medical journal of the Islamic Republic of Iran · 2025Article
- Molecular circadian clock disruption in the leukocytes of individuals with type 2 diabetes and overweight, and its relationship with leukocyte-endothelial interactions.Diabetologia · 2024Observational
- Association between multiple-heavy-metal exposures and systemic immune inflammation in a middle-aged and elderly Chinese general population.BMC public health · 2024Article
- Protective Effect of Betulin on Streptozotocin-Nicotinamide-Induced Diabetes in Female Rats.International journal of molecular sciences · 2024Article
- Circulating Leukocyte Subsets Before and After a Breast Cancer Diagnosis and Therapy.JAMA network open · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveAssociation between white blood cell (WBC) count and diabetes risk has been recently suggested. We assessed whether WBC count is an independent risk factor for diabetes incidence among young healthy adults. RESEARCH DESIGN AND
methodsWBC count was measured in 24,897 young (mean age 30.8 ± 5.36 years), normoglycemic men with WBC range of 3,000 to 12,000 cells/mm(3). Participants were periodically screened for diabetes during a mean follow-up of 7.5 years.
resultsDuring 185,354 person-years of follow-up, diabetes was diagnosed in 447 subjects. A multivariate model adjusted for age, BMI, family history of diabetes, physical activity, and fasting glucose and triglyceride levels revealed a 7.6% increase in incident diabetes for every increment of 1,000 cells/mm(3) (P = 0.046). When grouped in quintiles, a baseline WBC count above 6,900 cells/mm(3) had an independent 52% increase in diabetes risk (hazard ratio 1.52 [95% CI 1.06-2.18]) compared with the lowest quintile (WBC <5,400 cells/mm(3)). Men at the lowest WBC quintile were protected from diabetes incidence even in the presence of overweight, family history of diabetes, or elevated triglyceride levels. After simultaneous control for risk factors, BMI was the primary contributor of the variation in multivariate models (P < 0.001), followed by age and WBC count (P < 0.001), and family history of diabetes and triglyceride levels (P = 0.12).
conclusionsWBC count, a commonly used and widely available test, is an independent risk factor for diabetes in young men at values well within the normal range.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.