ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Spinal cord ependymomas in children and adolescents.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Bilateral Papilledema in a Child with Spinal Myxopapillary Ependymoma: A Case Report.The American journal of case reports · 2025Article
- Ependymal Tumors: Overview of the Recent World Health Organization Histopathologic and Genetic Updates with an Imaging Characteristic.AJNR. American journal of neuroradiology · 2024Review
- Ependymoma from Benign to Highly Aggressive Diseases: A Review.Advances and technical standards in neurosurgery · 2024Review
- Article
- Current management in the treatment of intramedullary ependymomas in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Changes to pediatric brain tumors in 2021 World Health Organization classification of tumors of the central nervous system.Pediatric radiology · 2023Review
- Essential Management of Pediatric Brain Tumors.Children (Basel, Switzerland) · 2022Review
- Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas.Acta neuropathologica communications · 2021Article
- High frequency of disease progression in pediatric spinal cord low-grade glioma (LGG): management strategies and results from the German LGG study group.Neuro-oncology · 2021Article
- Pediatric primary high-grade spinal glioma: a National Cancer Database analysis of current patterns in treatment and outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Surgical outcome and prognostic factors in spinal cord ependymoma: a single-center, long-term follow-up study.Therapeutic advances in neurological disorders · 2021Article
- Triad of meningothelial meningioma, rhabdoid meningioma and ependymoma: successful management of an extremely rare case.Journal of surgical case reports · 2020Article
- Current and Emerging Methods of Management of Ependymoma.Current oncology reports · 2019Review
- Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.Oncotarget · 2017Article
- Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database.Journal of neuro-oncology · 2016Article
- Radiation therapy after subtotal resection of pediatric grade II/III spinal ependymomas: what is the evidence?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Clinical features and long-term outcomes of intraspinal ependymomas in pediatric patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Pediatric spinal ependymomas: an unpredictable and puzzling disease. Long-term follow-up of a single consecutive institutional series of ten patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Integrative molecular characterization of pediatric spinal ependymoma: the UK Children's Cancer and Leukaemia Group study.Neuro-oncology advancesArticle
- Impact of molecular classification on prognosis in children and adolescents with spinal ependymoma: Results from the HIT-MED database.Neuro-oncology advancesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpinal cord ependymomas are very rare among children and adolescents. Due to their rarity, our current knowledge of these tumors is based on case reports and few retrospective case series.
methodsThe present review summarizes the currently available literature on childhood spinal cord ependymomas.
resultsAlthough overall survival rates are favorable, relapse incidence is high, particularly in myxopapillary ependymomas. Since long-term follow-up data are provided in a limited number of studies only, the true relapse incidence is unknown. Maximal safe radical surgery is the backbone of treatment for children with spinal cord ependymomas, but the impact of adjuvant treatment on progression and survival is still unclear. Presently, the decision to initiate non-surgical treatment depends primarily on the WHO grade of the tumor and the extent of resection. In terms of the known side effects, early radiotherapy should be avoided in children with WHO grade II spinal cord ependymomas irrespective of the extent of resection but is indicated in anaplastic spinal cord ependymomas both after complete and incomplete resection. The high relapse incidence in myxopapillary ependymomas argue for the use of early radiotherapy, but its definitive impact on progression has to be proven in larger series. Close surveillance is important due to the high recurrence rate in all patients with spinal cord ependymomas.
conclusionProspective collection of both clinical and molecular data from a greater number of patients with spinal cord ependymomas within an international collaboration is the prerequisite to establish standardized management guidelines for these rare CNS tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.