ArticlePlant physiology2012
Structural, functional, and evolutionary analysis of the unusually large stilbene synthase gene family in grapevine.
Article in Plant physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 150 citations in OpenAlex.
- Recent Advances in Physiological and Biochemical Responses of Grapevines to Downy Mildew Infection.Plants (Basel, Switzerland) · 2026Review
- Stilbenes from Vine Extracts: Therapeutic Potential and Mechanisms.International journal of molecular sciences · 2025Review
- VqERF1B-VqERF062-VqNSTS2 transcriptional cascade enhances stilbene biosynthesis and resistance to powdery mildew in grapevine.Plant biotechnology journal · 2025Article
- Review
- Advances in the molecular mechanism of grapevine resistance to fungal diseases.Molecular horticulture · 2025Review
- A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis.Applied microbiology and biotechnology · 2024Article
- The Stilbene Synthase Family inGenes · 2023Article
- Antioxidants of Non-Enzymatic Nature: Their Function in Higher Plant Cells and the Ways of Boosting Their Biosynthesis.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- VqMAPK3/VqMAPK6, VqWRKY33, andHorticulture research · 2023Article
- The first chromosome-levelHorticulture research · 2023Article
- Role of Cytochrome P450 Enzyme in Plant Microorganisms' Communication: A Focus on Grapevine.International journal of molecular sciences · 2023Review
- Alfin-like transcription factor VqAL4 regulates a stilbene synthase to enhance powdery mildew resistance in grapevine.Molecular plant pathology · 2023Article
- Weighted Gene Co-Expression Network Analysis to Explore Hub Genes of Resveratrol Biosynthesis in Exocarp and Mesocarp of 'Summer Black' Grape.Plants (Basel, Switzerland) · 2023Article
- A recessive mutation in muscadine grapes causes berry color-loss without influencing anthocyanin pathway.Communications biology · 2022Article
- Effect ofPlants (Basel, Switzerland) · 2022Article
- The flying spider-monkey tree fern genome provides insights into fern evolution and arborescence.Nature plants · 2022Article
- Expression of a Stilbene Synthase Gene from thePlants (Basel, Switzerland) · 2022Article
- Differential Response of Phenol Metabolism Associated with Antioxidative Network in Elicited Grapevine Suspension Cultured Cells under Saline Conditions.Antioxidants (Basel, Switzerland) · 2022Article
- Vine Shoots as a Source ofFoods (Basel, Switzerland) · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stilbenes are a small family of phenylpropanoids produced in a number of unrelated plant species, including grapevine (Vitis vinifera). In addition to their participation in defense mechanisms in plants, stilbenes, such as resveratrol, display important pharmacological properties and are postulated to be involved in the health benefits associated with a moderate consumption of red wine. Stilbene synthases (STSs), which catalyze the biosynthesis of the stilbene backbone, seem to have evolved from chalcone synthases (CHSs) several times independently in stilbene-producing plants. STS genes usually form small families of two to five closely related paralogs. By contrast, the sequence of grapevine reference genome (cv PN40024) has revealed an unusually large STS gene family. Here, we combine molecular evolution and structural and functional analyses to investigate further the high number of STS genes in grapevine. Our reannotation of the STS and CHS gene families yielded 48 STS genes, including at least 32 potentially functional ones. Functional characterization of nine genes representing most of the STS gene family diversity clearly indicated that these genes do encode for proteins with STS activity. Evolutionary analysis of the STS gene family revealed that both STS and CHS evolution are dominated by purifying selection, with no evidence for strong selection for new functions among STS genes. However, we found a few sites under different selection pressures in CHS and STS sequences, whose potential functional consequences are discussed using a structural model of a typical STS from grapevine that we developed.
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