SynthesisCancer causes & control : CCC2012
ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium.
Synthesis in Cancer causes & control : CCC, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Association of ABO polymorphisms and pancreatic Cancer/ Cardiocerebrovascular disease: a meta-analysis.BMC medical genetics · 2020Pooled it
- Association between ABO gene polymorphism (rs505922) and cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Pooled it
- Identification of six new susceptibility loci for invasive epithelial ovarian cancer.Nature genetics · 2015Pooled it
- Association between ABO and Duffy blood types and circulating chemokines and cytokines.Genes and immunity · 2021Trial
- ABO gene polymorphisms: a molecular bridge linking disease susceptibility to therapeutic outcomes.Frontiers in medicine · 2026Review
- ABO Blood Group and the Risk and Prognosis of Diffuse Large B-Cell Lymphoma.Cancer management and research · 2025Article
- The Prognostic Impact of ABO Blood Group in Hepatocellular Carcinoma Following Hepatectomy.Cancers · 2023Article
- The Value of ABO Blood Group and Complete Blood Count for the Prognosis Analysis of Gastric Cancer Patients.OncoTargets and therapy · 2020Article
- AB0 Blood Group and Ovarian Cancer Survival.Journal of Cancer · 2019Article
- ABO Blood Group and Diabetes Mellitus Influence the Risk for Pancreatic Cancer in a Population from China.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
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- ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women.Medical oncology (Northwood, London, England) · 2016Article
- The role of the histoblood ABO group in cancer.Future science OA · 2016Review
- Epidemiologic characteristics of oral cancer: single-center analysis of 4097 patients from the Sun Yat-sen University Cancer Center.Chinese journal of cancer · 2016Article
- Impact of ABO blood group on the prognosis of patients undergoing surgery for esophageal cancer.BMC surgery · 2015Article
- The ABO blood group is an independent prognostic factor in patients with resected non-small cell lung cancer.Journal of epidemiology · 2015Article
- Prognostic Impact of ABO Blood Group on the Survival in Patients with Ovarian Cancer.Journal of Cancer · 2015Article
- Is there a predictive significance of ABO blood group on chemotherapy-induced thrombocytopenia in patients with stage III colon cancer?Medical oncology (Northwood, London, England) · 2015Article
Corrections and comments
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Authors and funding
24 authors at 12 institutions in 3 countries.
Funding
Abstract
purposePrevious studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results.
methodsIn eight studies participating in the Ovarian Cancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis.
resultsCompared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI: 0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes.
conclusionConsistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.