ArticleLab on a chip2012
Engineering of polarized tubular structures in a microfluidic device to study calcium phosphate stone formation.
Article in Lab on a chip, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Revolutionizing nephrology research: expanding horizons with kidney-on-a-chip and beyond.Frontiers in bioengineering and biotechnology · 2024Review
- Application of microfluidic chips in the simulation of the urinary system microenvironment.Materials today. Bio · 2023Review
- Differential biomolecular recognition by syntheticJournal of materials chemistry. B · 2021Article
- Tannic acid attenuates vascular calcification-induced proximal tubular cells damage through paracrine signaling.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- Microfluidic lumen-based systems for advancing tubular organ modeling.Chemical Society reviews · 2020Review
- Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics.NPJ precision oncology · 2020Review
- Microfluidic Cell Trapping for Single-Cell Analysis.Micromachines · 2019Article
- Melamine promotes calcium crystal formation in three-dimensional microfluidic device.Scientific reports · 2019Article
- Mimicking the Kidney: A Key Role in Organ-on-Chip Development.Micromachines · 2016Review
- A Role for 3D Printing in Kidney-on-a-Chip Platforms.Current transplantation reports · 2016Article
- Tissue-engineered kidney disease models.Advanced drug delivery reviews · 2014Review
- Vascular Calcification and Stone Disease: A New Look towards the Mechanism.Journal of cardiovascular development and diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This communication describes the formation of tubular structures with a circular cross-section by growing epithelial cells in a microfluidic (MF) device. Here we show for the first time that it is possible to form a monolayer of polarized cells, embedded within the MF device which can function as an in vivo epithelia. We showed: i) the overexpression of specific protein(s) of interest (i.e., ion channel and transport proteins) is feasible inside tubular structures in MFs; ii) the functional kinetic information of Ca(2+) in cells can be measured by microflurometry using cell permeable Ca(2+) probe under confocal microscope; and iii) calcium phosphate stones can be produced in real time in MFs with Ca(2+) transporting epithelia. These data suggest that tubular structures inside this MF platform can be used as a suitable model to understand the molecular and pharmacological basis of calcium phosphate stone formation in the epithelial or other similar cellular micro environments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.