Evidence map›Paper›PMID 22960599›Full record

ReviewBiochimica et biophysica acta

TFIIB-related factors in RNA polymerase I transcription.

Bruce A Knutson, Steven Hahn

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Journal of fungi (Basel, Switzerland) · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
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  11. Review
  12. Article
  13. Article
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  15. Review
  16. Article
  17. Nuclear PI3K signaling in cell growth and tumorigenesis.Frontiers in cell and developmental biology · 2015
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Bruce A KnutsonFred Hutchinson Cancer Research Center, Division of Basic Sciences, 1100 Fairview Ave. N, P.O. Box 19024, Mailstop A1-162, Seattle, WA 98109, USA. bknutson@fhcrc.org
Steven Hahn
Fred Hutch Cancer Center · US

Funding

MOLECULAR ANALYSIS OF RNAPIII TRANSCRIPTION INITIATIONR01GM053451 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HAHN, STEVEN M · 1995 to 2020
$11.4M
NIGMS NIH HHS R01 GM053451
6 · The paper itself

Abstract

Eukaryotic RNA polymerases (Pol) I, II, III and archaeal Pol use a related set of general transcription factors to recognize promoter sequences and recruit Pol to promoters and to function at key points in the transcription initiation mechanism. The TFIIB-like general transcription factors (GTFs) function during several important and conserved steps in the initiation pathway for Pols II, III, and archaeal Pol. Until recently, the mechanism of Pol I initiation seemed unique, since it appeared to lack a GTF paralogous to the TFIIB-like proteins. The surprising recent discovery of TFIIB-related Pol I general factors in yeast and humans highlights the evolutionary conservation of transcription initiation mechanisms for all eukaryotic and archaeal Pols. These findings reveal new roles for the function of the Pol I GTFs and insight into the function of TFIIB-related factors. Models for Pol I transcription initiation are reexamined in light of these recent findings. This article is part of a Special Issue entitled: Transcription by Odd Pols.

Indexed as

Transcription, GeneticAnimalsEukaryotaHumansProtein Interaction Domains and MotifsRNA Polymerase ISequence Homology, Amino AcidTranscription Factor TFIIBRNA Polymerase ITranscription Factor TFIIB

Identifiers

PMID22960599
PMCPMC3556359
OpenAlexW2083086919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.