Evidence map›Paper›PMID 22960253›Full record

ReviewSeminars in cell & developmental biology2012

Development and homeostasis of the sebaceous gland.

Catherin Niemann, Valerie Horsley

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
  2. Article
  3. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo-bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  8. Review
  9. Review
  10. Extraction and Quantification of Skin Immune Cells and Skin Lipids.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  11. Article
  12. Article
  13. Epigenetic orchestration of RNA mInternational journal of biological sciences · 2025
    Review
  14. Review
  15. Article
  16. The development of hair follicles and nail.Developmental biology · 2024
    Review
  17. Article
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Catherin NiemannCenter for Molecular Medicine Cologne, University of Cologne, Germany. cnieman1@uni-koeln.de
Valerie Horsley

Funding

Extrinsic Regulation of Epidermal HomeostatasisR01AR060295 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2011 to 2016
$2.2M
Regulation of Sebaceous Gland DevelopmentR00AR054775 · NIAMS · YALE UNIVERSITY · PI HORSLEY, VALERIE · 2009 to 2011
$732k
Regulation of Sebaceous Gland DevelopmentK99AR054775 · NIAMS · ROCKEFELLER UNIVERSITY · PI HORSLEY, VALERIE · 2007 to 2008
$180k
NIAMS NIH HHS K99 AR054775NIAMS NIH HHS R00 AR054775NIAMS NIH HHS R01 AR060295
6 · The paper itself

Abstract

The important role of epidermal appendages especially the sebaceous gland has only recently been recognized. In particular, it has been convincingly shown that normal development and maintenance of the sebaceous gland are required for skin homeostasis since atrophic sebaceous glands and disturbances in sebaceous lipid composition result in major defects of the physiological barrier and maintenance of the skin. Consequently, it is important to unravel the signaling network controlling proper sebaceous lineage differentiation in mammalian skin and to understand the underlying mechanisms leading to severe skin diseases, including abnormal proliferation and differentiation of the gland, defects of the lipid metabolism and barrier, as well as sebaceous tumor formation. Over the last years, results from transgenic and knock out mouse models manipulating distinct signaling pathways in the skin as well as the detailed analysis of human sebaceous gland-derived cell lines provided new insights into crucial mediators balancing proliferation and differentiation of the sebaceous gland. Here, we discuss our current knowledge of in vivo mechanisms of sebaceous gland development, maintenance and disorders and highlight recent contributions to the field of sebaceous gland biology.

Indexed as

HomeostasisAnimalsHumansSebaceous GlandsSignal TransductionSkin DiseasesTranscription, Genetic

Identifiers

PMID22960253
PMCPMC5595243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.