ArticleJournal of neuroscience methods2012
Hemisection spinal cord injury in rat: the value of intraoperative somatosensory evoked potential monitoring.
Article in Journal of neuroscience methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Injury in Rats.Journal of visualized experiments : JoVE · 2024Article
- A pig model of symptomatic spinal epidural hematoma.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Spinal Cord Injury in the Mouse Using the Infinite Horizon Spinal Cord Impactor.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A novel bone-thinning technique for transcranial stimulation motor-evoked potentials in rats.Scientific reports · 2021Article
- Review
- Modulation of autophagy for neuroprotection and functional recovery in traumatic spinal cord injury.Neural regeneration research · 2020Review
- Injectable Extracellular Matrix Hydrogels as Scaffolds for Spinal Cord Injury Repair.Tissue engineering. Part A · 2016Article
- Topography of Synchronization of Somatosensory Evoked Potentials Elicited by Stimulation of the Sciatic Nerve in Rat.Frontiers in computational neuroscience · 2016Article
- A consistent, quantifiable, and graded rat lumbosacral spinal cord injury model.Journal of neurotrauma · 2015Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Techniques used to produce partial spinal cord injuries in animal models have the potential for creating variability in lesions. The amount of tissue affected may influence the functional outcomes assessed in the animals. The recording of somatosensory evoked potentials (SSEPs) may be a valuable tool for assessing the extent of lesion applied in animal models of traumatic spinal cord injury (SCI). Intraoperative tibial SSEP recordings were assessed during surgically induced lateral thoracic hemisection SCI in Sprague-Dawley rats. The transmission of SSEPs, or lack thereof, was determined and compared against the integrity of the dorsal funiculi on each side of the spinal cord upon histological sectioning. An association was found between the presence of an SSEP signal and presence of intact dorsal funiculus tissue. The relative risk is 4.50 (95% confidence interval: 1.83-11.08) for having an intact dorsal funiculus when the ipsilateral SSEP was present compared to when it was absent. Additionally, the amount of spared spinal cord tissue correlates with final functional assessments at nine weeks post injury: BBB (linear regression, R²=0.618, p<0.001) and treadmill test (linear regression, R²=0.369, p=0.016). Therefore, we propose intraoperative SSEP monitoring as a valuable tool to assess extent of lesion and reduce variability between animals in experimental studies of SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.