ArticleThe American journal of pathology2012
Spontaneous latency in a rabbit model of pulmonary tuberculosis.
Article in The American journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 74 citations in OpenAlex.
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- The study of immunological markers in tuberculosis across animal models and its translation to human research.Lab animal · 2026Review
- Inflammasome Activation Differences Underpin DifferentMedComm · 2025Article
- Dormant yet dangerous: the role of cell rest in perseverance.Future microbiology · 2025Review
- Model systems to studyFrontiers in cellular and infection microbiology · 2025Review
- Methods and Models for StudyingInternational journal of molecular sciences · 2024Review
- Genomic variations in Mycobacterium tuberculosis from the lungs and blood of HIV-infected individuals in Uganda: insights into compartmentalization.African health sciences · 2024Article
- Mathematical modeling suggests heterogeneous replication of Mycobacterium tuberculosis in rabbits.PLoS computational biology · 2024Article
- Pathogenesis of Post-Tuberculosis Lung Disease: Defining Knowledge Gaps and Research Priorities at the Second International Post-Tuberculosis Symposium.American journal of respiratory and critical care medicine · 2024Review
- Mathematical modeling suggests heterogeneous replication ofbioRxiv : the preprint server for biology · 2024Article
- Immunopathology of PulmonaryInternational journal of molecular sciences · 2024Article
- An Update to Novel Therapeutic Options for Combating Tuberculosis: Challenges and Future Prospectives.Current pharmaceutical biotechnology · 2024Review
- Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals.Frontiers in immunology · 2024Review
- Animal models for COVID-19 and tuberculosis.Frontiers in immunology · 2023Review
- Review
- Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology.Communications biology · 2021Article
- In Vitro Miniaturized Tuberculosis Spheroid Model.Biomedicines · 2021Article
- Applications of Transcriptomics and Proteomics for Understanding Dormancy and Resuscitation inFrontiers in microbiology · 2021Review
- Inflammatory Determinants of Differential Tuberculosis Risk in Pre-Adolescent Children and Young Adults.Frontiers in immunology · 2021Article
- Novel Assay Platform to Evaluate Intracellular Killing ofFrontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is an exquisitely adapted human pathogen capable of surviving for decades in the lungs of immune-competent individuals in the absence of disease. The World Health Organization estimates that 2 billion people have latent TB infection (LTBI), defined by a positive immunological response to Mtb antigens, with no clinical signs of disease. A better understanding of host and pathogen determinants of LTBI and subsequent reactivation would benefit TB control efforts. Animal models of LTBI have been hampered generally by an inability to achieve complete bacillary clearance. Herein, we have characterized a rabbit model of LTBI in which, similar to most humans, complete clearance of pulmonary Mtb infection and pathological characteristics occurs spontaneously. The evidence that Mtb-CDC1551-infected rabbits achieve LTBI, rather than sterilization, is based on the ability of the bacilli to be reactivated after immune suppression. These rabbits showed early activation of T cells and macrophages and an early peak in the TNFα level, which decreased in association with clearance of bacilli from the lungs. In the absence of sustained tumor necrosis factor-α production, no necrosis was seen in the evolving lung granulomas. In addition, bacillary control was associated with down-regulation of several metalloprotease genes and an absence of lung fibrosis. This model will be used to characterize molecular markers of protective immunity and reactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.