Trial reportAmerican journal of ophthalmology2012
Nocardia keratitis: clinical course and effect of corticosteroids.
Trial report in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Topical antibiotics for treating bacterial keratitis: a network meta-analysis.The Cochrane database of systematic reviews · 2025Pooled it
- Nocardiosis: A Neglected Disease.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2020Pooled it
- Topical corticosteroids as adjunctive therapy for bacterial keratitis.The Cochrane database of systematic reviews · 2014Pooled it
- Early addition of topical corticosteroids in the treatment of bacterial keratitis.JAMA ophthalmology · 2014Trial
- Visual outcomes in treated bacterial keratitis: four years of prospective follow-up.Investigative ophthalmology & visual science · 2014Trial
- The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial.American journal of ophthalmology · 2014Trial
- Real-World Management and Patterns of Antibiotic Use in Patients with Keratitis and Ocular Surface Injuries: A Nationwide Survey Study in Spain.Antibiotics (Basel, Switzerland) · 2026Article
- Diagnosis and management of paediatricOxford medical case reports · 2026Article
- Whole-genome sequencing and analysis of Nocardia veterana isolates from keratitis patients.Molecular genetics and genomics : MGG · 2026Article
- Advances in the molecular pathogenesis ofFrontiers in cellular and infection microbiology · 2026Review
- Nocardia infection following ocular surface surgery.International ophthalmology · 2023Article
- Nocardia keratitis: amikacin nonsusceptibility, risk factors, and treatment outcomes.Journal of ophthalmic inflammation and infection · 2022Article
- Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance.Eye (London, England) · 2021Review
- Current diagnostic tools and management modalities of Nocardia keratitis.Journal of ophthalmic inflammation and infection · 2020Review
- Pulmonary Nocardia ignorata Infection in Gardener, Iran, 2017.Emerging infectious diseases · 2020Article
- Update on the Management of Infectious Keratitis.Ophthalmology · 2017Review
- Trends in antibiotic resistance in bacterial keratitis isolates from South India.The British journal of ophthalmology · 2017Article
- Use of adjunctive topical corticosteroids in bacterial keratitis.Current opinion in ophthalmology · 2016Review
- Role of steroids in the treatment of bacterial keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Efficacy of systemic vitamin C supplementation in reducing corneal opacity resulting from infectious keratitis.Medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo compare the clinical course of Nocardia species keratitis with keratitis resulting from other bacterial organisms and to assess the effect of corticosteroids as adjunctive therapy using data collected from the Steroids for Corneal Ulcers Trial.
designSubgroup analysis of a randomized controlled trial.
methodssetting: Multicenter randomized controlled trial. study population: Five hundred patients with bacterial keratitis randomized 1:1 to topical corticosteroid or placebo who had received at least 48 hours of topical moxifloxacin. intervention/observation procedure: Topical prednisolone phosphate 1% or placebo and clinical course of Nocardia keratitis. main outcome measures: Best spectacle-corrected visual acuity and infiltrate or scar size at 3 months from enrollment.
resultsOf 500 patients enrolled in the trial, 55 (11%) had a Nocardia corneal ulcer. Patients with Nocardia ulcers had better presentation visual acuity compared with non-Nocardia ulcers (median Snellen visual acuity, 20/45, compared with 20/145; P < .001) and comparable 3-month visual acuity (median, 20/25, vs 20/40; P = .25). Nocardia ulcers had approximately 2 lines less of improvement in visual acuity compared with non-Nocardia ulcers (0.21 logarithm of the minimal angle of resolution; 95% confidence interval, 0.09 to 0.33 logarithm of the minimal angle of resolution; P = .001). This difference may reflect the better starting visual acuity in patients with Nocardia ulcers. In Nocardia ulcers, corticosteroids were associated with an average 0.4-mm increase in 3-month infiltrate or scar size (95% confidence interval, 0.03 to 0.77 mm; P = .03).
conclusionsNocardia ulcers responded well to treatment. They showed less overall improvement in visual acuity than non-Nocardia ulcers, but had better presentation acuity. Corticosteroids may be associated with worse outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.