ArticleThe Annals of thoracic surgery2012
In-parallel attachment of a low-resistance compliant thoracic artificial lung under rest and simulated exercise.
Article in The Annals of thoracic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Oxygenation performance assessment of an artificial lung in different central anatomic configurations.The International journal of artificial organs · 2023Article
- A Model of Pediatric End-Stage Lung Failure in Small Lambs <20 kg.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2020Article
- Fourteen Day In Vivo Testing of a Compliant Thoracic Artificial Lung.ASAIO journal (American Society for Artificial Internal Organs : 1992)Article
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4 authors.
Funding
Abstract
backgroundPrevious thoracic artificial lungs (TALs) had blood flow impedance greater than that of the natural lungs, which could cause abnormal pulmonary hemodynamics. New compliant TALs (cTALs), however, have an impedance lower than that of the natural lung.
methodsIn this study, a cTAL of new design was attached between the pulmonary artery (PA) and the left atrium (LA) in 5 sheep (60.2 ± 1.9 kg). A distal PA band was placed to control the percentage of cardiac output (CO) routed to the cTAL. Rest and exercise conditions were simulated using a continuous dobutamine infusion of 0 and 5 μg/kg/min, respectively. At each dose, a hemodynamic data set was acquired at baseline (no flow to the cTAL), and 60%, 75%, and 90% of CO was shunted to the cTAL.
resultsDevice resistance did not vary with blood flow rate, averaging 0.51 ± 0.03 mm Hg/(L/min). Under all conditions, CO was not significantly different from baseline. Pulmonary system impedance increased above baseline only with 5 μg/kg/min of dobutamine and 90% of CO diverted to the cTAL.
conclusionsResults indicated minimal changes in pulmonary hemodynamics during PA-LA cTAL attachment for high device flows under rest and exercise conditions.
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