ArticleHearing research2012
How are inner hair cells stimulated? Evidence for multiple mechanical drives.
Article in Hearing research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 94 citations in OpenAlex.
- Inner Ear Organoids: Recent Progress and Challenges.Stem cell reviews and reports · 2026Review
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- Coupled oscillator mechanism extends the amplifying effect of outer hair cells to high frequencies.Scientific reports · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.Research square · 2025Article
- Effectiveness of Outer Hair Cells as Cochlear Amplifier: Coupled Oscillator Models.bioRxiv : the preprint server for biology · 2025Article
- How Exceptional Is the Ear?Journal of the Association for Research in Otolaryngology : JARO · 2025Review
- The cortilymph wave: Its relation to the traveling wave, auditory-nerve responses, and low-frequency downward glides.Hearing research · 2025Review
- Tectorial membrane: structure, function, and its implications for hearing loss.Frontiers in neurology · 2025Review
- The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes.International journal of molecular sciences · 2023Review
- Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
- The Spectral Extent of Phasic Suppression of Loudness and Distortion-Product Otoacoustic Emissions by Infrasound and Low-Frequency Tones.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Inner hair cell stereocilia displacement in response to focal stimulation of the basilar membrane in the ex vivo gerbil cochlea.Hearing research · 2021Article
- Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A flexible anatomical set of mechanical models for the organ of Corti.Royal Society open science · 2021Article
- In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.Communications biology · 2021Article
- Fluid Jet Stimulation of Auditory Hair Bundles Reveal Spatial Non-uniformities and Two Viscoelastic-Like Mechanisms.Frontiers in cell and developmental biology · 2021Article
- Similarities and Differences Between Vestibular and Cochlear Systems - A Review of Clinical and Physiological Evidence.Frontiers in neuroscience · 2021Review
- The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases.Frontiers in cell and developmental biology · 2021Review
- Utricular Sensitivity during Hydrodynamic Displacements of the Macula.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recent studies indicate that the gap over outer hair cells (OHCs) between the reticular lamina (RL) and the tectorial membrane (TM) varies cyclically during low-frequency sounds. Variation in the RL-TM gap produces radial fluid flow in the gap that can drive inner hair cell (IHC) stereocilia. Analysis of RL-TM gap changes reveals three IHC drives in addition to classic SHEAR. For upward basilar-membrane (BM) motion, IHC stereocilia are deflected in the excitatory direction by SHEAR and OHC-MOTILITY, but in the inhibitory direction by TM-PUSH and CILIA-SLANT. Upward BM motion causes OHC somatic contraction which tilts the RL, compresses the RL-TM gap over IHCs and expands the RL-TM gap over OHCs, thereby producing an outward (away from the IHCs) radial fluid flow which is the OHC-MOTILITY drive. For upward BM motion, the force that moves the TM upward also compresses the RL-TM gap over OHCs causing inward radial flow past IHCs which is the TM-PUSH drive. Motions that produce large tilting of OHC stereocilia squeeze the supra-OHC RL-TM gap and caused inward radial flow past IHCs which is the CILIA-SLANT drive. Combinations of these drives explain: (1) the reversal at high sound levels of auditory nerve (AN) initial peak (ANIP) responses to clicks, and medial olivocochlear (MOC) inhibition of ANIP responses below, but not above, the ANIP reversal, (2) dips and phase reversals in AN responses to tones in cats and chinchillas, (3) hypersensitivity and phase reversals in tuning-curve tails after OHC ablation, and (4) MOC inhibition of tail-frequency AN responses. The OHC-MOTILITY drive provides another mechanism, in addition to BM motion amplification, that uses active processes to enhance the output of the cochlea. The ability of these IHC drives to explain previously anomalous data provides strong, although indirect, evidence that these drives are significant and presents a new view of how the cochlea works at frequencies below 3 kHz.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.