ArticleFertility and sterility2012
Effects of resveratrol on growth and function of rat ovarian granulosa cells.
Article in Fertility and sterility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03446625 (Resveratrol as a Preventive Treatment of Ovarian Hyperstimulation Syndrome), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Resveratrol as a Preventive Treatment of Ovarian Hyperstimulation Syndrome
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials.The Pan African medical journal · 2023Pooled it
- Resveratrol and Markers of Polycystic Ovary Syndrome: a Systematic Review of Animal and Clinical Studies.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial.Journal of assisted reproduction and genetics · 2019Trial
- Resveratrol supplementation mitigates age-related declines in egg production, quality, and ovarian health of laying hens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Effects of Resveratrol-Loaded Nanoparticles on Follicular Survival, Stromal Integrity and Activity of Endogenous Free-Radical Scavengers in Bovine Ovarian Cortical Slices Cultured In Vitro.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Curative potential of resveratrol and pterostilbene against epoxy resin-induced reproductive toxicity in female rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Article
- Resveratrol Promotes Proliferation, Antioxidant Properties, and Progesterone Production in Yak (Animals : an open access journal from MDPI · 2024Article
- Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review.Frontiers in pharmacology · 2022Review
- Low Doses of Resveratrol Protect Human Granulosa Cells from Induced-Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Updates on molecular and environmental determinants of luteal progesterone production.Molecular and cellular endocrinology · 2020Review
- Review
- Potential Adverse Effects of Resveratrol: A Literature Review.International journal of molecular sciences · 2020Review
- Biphasic Dose-Response Induced by Phytochemicals: Experimental Evidence.Journal of clinical medicine · 2020Review
- Exploring the Pharmacological Mechanism of Quercetin-Resveratrol Combination for Polycystic Ovary Syndrome: A Systematic Pharmacological Strategy-Based Research.Scientific reports · 2019Article
- Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study.Journal of ovarian research · 2018Article
- Biological effects of combined resveratrol and vitamin D3 on ovarian tissue.Journal of ovarian research · 2017Article
- Protective effects of resveratrol against mancozeb induced apoptosis damage in mouse oocytes.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo evaluate the effects of resveratrol on growth and function of granulosa cells. Previously, we demonstrated that resveratrol exerts profound proapoptotic effects on theca-interstitial cells.
designIn vitro study.
settingResearch laboratory. ANIMAL(S): Immature Sprague-Dawley female rats. INTERVENTION(S): Granulosa cells were cultured in the absence or presence of resveratrol. MAIN OUTCOME MEASURE(S): DNA synthesis was determined by thymidine incorporation assay, apoptosis by activity of caspases 3/7, cell morphology by immunocytochemistry, steroidogenesis by mass spectrometry, antimüllerian hormone (AMH), and vascular endothelial growth factor (VEGF) expression by polymerase chain reaction and Western blot. RESULT(S): Resveratrol induced a biphasic effect on DNA synthesis, whereby a lower concentration stimulated thymidine incorporation and higher concentrations inhibited it. Additionally, resveratrol slightly increased the cell number and modestly decreased the activity of caspases 3/7 with no effect on cell morphology or progesterone production. However, resveratrol decreased aromatization and VEGF expression, whereas AMH expression remained unaltered. CONCLUSION(S): Resveratrol, by exerting cytostatic but not cytotoxic effects, together with antiangiogenic actions mediated by decreased VEGF in granulosa cells, may alter the ratio of theca-to-granulosa cells and decrease vascular permeability, and therefore may be of potential therapeutic use in conditions associated with highly vascularized theca-interstitial hyperplasia and abnormal angiogenesis, such as those seen in women with polycystic ovary syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.