ArticleMayo Clinic proceedings2012
Low lung function and risk of type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 9 (TOPICS 9).
Article in Mayo Clinic proceedings, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Chronic obstructive pulmonary disease, lung function and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies.BMC pulmonary medicine · 2020Pooled it
- Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness.Journal of personalized medicine · 2022Article
- The Risk Factors for Development of Type 2 Diabetes: Panasonic Cohort Study 4.International journal of environmental research and public health · 2022Article
- Review
- Genetic Correlation and Bidirectional Causal Association Between Type 2 Diabetes and Pulmonary Function.Frontiers in endocrinology · 2021Article
- Non-linear association between diabetes mellitus and pulmonary function: a population-based study.Respiratory research · 2020Article
- The Association Between Lung Function and Type 2 Diabetes in Koreans.Osong public health and research perspectives · 2020Article
- Article
- Relationship between pulmonary function and elevated glycated hemoglobin levels in health checkups: A cross-sectional observational study in Japanese participants.Journal of epidemiology · 2017Observational
- Impaired lung function is associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in middle-aged and elderly Chinese.BMC endocrine disorders · 2017Article
- The temporal relationship between poor lung function and the risk of diabetes.BMC pulmonary medicine · 2016Article
- The relation between insulin resistance and lung function: a cross sectional study.BMC pulmonary medicine · 2015Article
- Association of glycemic status with impaired lung function among recipients of a health screening program: a cross-sectional study in Japanese adults.Journal of epidemiology · 2014Article
- Cross-sectional and prospective study of the association between lung function and prediabetes.BMJ open · 2013Article
- Chronic obstructive pulmonary disease and glucose metabolism: a bitter sweet symphony.Cardiovascular diabetology · 2012Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of elevated fasting plasma glucose (FPG) and hemoglobin A(1c) (HbA(1c)) concentrations on lung dysfunction and to prospectively investigate whether reduced lung function would be independently predictive of diabetes. PARTICIPANTS AND
methodsFrom January 6, 1997, through December 22, 2008, we observed 5346 men with no history of diabetes or lung dysfunction. Hazard ratios (HRs) for incident diabetes (FPG ≥126 mg/dL, HbA(1c) ≥6.5%, or self-reported clinician-diagnosed diabetes) were estimated for spirometry indices as continuous and categorical variables.
resultsElevated HbA(1c) concentrations within the normal range were significantly and more strongly associated with reduced forced vital capacity and forced expiratory volume in the first second after expiration (FEV(1)) than were FPG concentrations. During a 4.0-year follow-up, diabetes developed in 214 individuals. A 10-point decrease in percentage of FEV(1) predicted value was associated with an increased HR of 1.21 (95% confidence interval [CI], 1.09-1.34; P=.001) for diabetes after adjustment for demographic factors and body mass index. This association remained significant even after adjustment for metabolic factors, smoking status, and FPG or HbA(1c) concentrations but was attenuated substantially after adjustment for baseline HbA(1c) values (HR, 1.13; 95% CI, 1.01-1.26; P=.03). Lower quartile (Q) categories of percentage of FEV(1) predicted value were associated with increased risk of diabetes independently of known predictors including HbA(1c) (HR, 1.73; 95% CI, 1.14-2.62 for Q1; and HR, 1.76; 95% CI, 1.15-2.69 for Q2).
conclusionReduced lung function was significantly related to chronic glycemic exposure within a normal range. Relatively low pulmonary function was an independent risk factor for diabetes in apparently healthy Japanese men.
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