ArticleCell stem cell2012
Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis.
Article in Cell stem cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Investigating increased hematopoietic stem cell fitness in a novel mouse model.Small GTPases · 2022Article
- Adaptive responses toProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture.FEBS letters · 2019Article
- Article
- The mitochondrial metabolic checkpoint and aging of hematopoietic stem cells.Current opinion in hematology · 2016Review
- mTORC signaling in hematopoiesis.International journal of hematology · 2016Review
- Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish.Journal of hematology & oncology · 2014Article
- Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.Molecular cell · 2014Article
- AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL.Leukemia · 2013Article
- Metabolic plasticity in stem cell homeostasis and differentiation.Cell stem cell · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Signaling involving PI3K and AKT regulates cell growth, partly through the mTOR kinase complexes 1 and 2. In this issue of Cell Stem Cell, Kalaitzidis et al. and Magee et al. reveal unique requirements for mTORC1 and mTORC2 signaling during blood development and leukemogenesis induced by loss of PTEN.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.