ArticleThe Journal of experimental medicine1990
Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron.
Article in The Journal of experimental medicine, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- A novel enhancer RNA, Hmrhl, positively regulates its host gene,Non-coding RNA research · 2019Article
- Genomic structure around joining segments and constant regions of swine T-cell receptor alpha/delta (TRA/TRD) locus.Immunology · 2003Article
- T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- An enhancer-blocking element between alpha and delta gene segments within the human T cell receptor alpha/delta locus.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Gene rearrangements and chromosomal translocations in T cell lymphoma--diagnostic applications and their limits.Virchows Archiv : an international journal of pathology · 1995Review
- Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor.Molecular and cellular biology · 1994Article
- Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8 alpha gene.Molecular and cellular biology · 1993Article
- SEF1 binding is important for T cell specific enhancers of genes for T cell receptor-CD3 subunits.Nucleic acids research · 1992Article
- A third tal-1 promoter is specifically used in human T cell leukemias.The Journal of experimental medicine · 1992Article
- Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells.Japanese journal of cancer research : Gann · 1992Article
- Identification of an essential site for transcriptional activation within the human T-cell receptor delta enhancer.Molecular and cellular biology · 1991Article
- The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- A T-cell specific TCR delta DNA binding protein is a member of the human GATA family.The EMBO journal · 1991Article
- Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.Molecular and cellular biology · 1991Article
- Identification of a T-cell-specific enhancer at the locus encoding T-cell antigen receptor gamma chain.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.The EMBO journal · 1991Article
- The SCL gene is formed from a transcriptionally complex locus.Molecular and cellular biology · 1990Article
- Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have defined transcriptional enhancing sequences inside the TCR-delta gene locus, using transient transfections with constructs containing DNA fragments cloned upstream to a reporter gene fused to a heterologous promoter. A 14-kb DNA region extending from the J delta 3 segment to 6 kb 3' to C delta was analyzed. We show the presence of positive regulatory sequences inside the J delta 3-C delta intron and have localized these sequences to two DNA fragments of approximately 300 and 258 bp. Analysis of cell specificity of the activation of such sequences demonstrates a T cell pattern for one of the two fragments. The nucleotide sequence of the T cell-specific element shows motifs sharing homology with previously described core enhancers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.