Evidence map›Paper›PMID 22958485›Full record

ReviewSeminars in nephrology2012

Signaling from the podocyte intercellular junction to the actin cytoskeleton.

Britta George, Lawrence B Holzman

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. Review
  3. The Life of a Kidney Podocyte.Acta physiologica (Oxford, England) · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Rap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity.Frontiers in cell and developmental biology · 2022
    Article
  8. Disruption of the exocyst induces podocyte loss and dysfunction.The Journal of biological chemistry · 2019
    Article
  9. Nephrin Signaling Results in IntegrinJournal of the American Society of Nephrology : JASN · 2019
    Article
  10. Article
  11. Montelukast improves the changes of cytoskeletal and adaptor proteins of human podocytes by interleukin-13.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Podocytes.F1000Research · 2016
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Britta GeorgeRenal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104, USA.
Lawrence B Holzman
University of Pennsylvania · US

Funding

Slit Diaphragm and Actin DynamicsR01DK080751 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HOLZMAN, LAWRENCE B. · 2008 to 2017
$3.6M
NIDDK NIH HHS DK080751NIDDK NIH HHS R01 DK080751
6 · The paper itself

Abstract

Observations of hereditary glomerular disease support the contention that podocyte intercellular junction proteins are essential for junction formation and maintenance. Genetic deletion of most of these podocyte intercellular junction proteins results in foot process effacement and proteinuria. This review focuses on the current understanding of molecular mechanisms by which podocyte intercellular junction proteins such as the nephrin-neph1-podocin-receptor complex coordinate cytoskeletal dynamics and thus intercellular junction formation, maintenance, and injury-dependent remodeling.

Indexed as

Actin CytoskeletonAnimalsHumansIntercellular JunctionsIntracellular Signaling Peptides and ProteinsMembrane ProteinsPodocytesSignal TransductionIntracellular Signaling Peptides and ProteinsKIRREL1 protein, humanMembrane ProteinsnephrinNPHS2 protein

Identifiers

PMID22958485
PMCPMC3438455
OpenAlexW2053357822

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.