Evidence map›Paper›PMID 22958367›Full record

ArticleMultidisciplinary respiratory medicine2012

Anatomy and neuro-pathophysiology of the cough reflex arc.

Mario Polverino, Francesca Polverino, Marco Fasolino, Filippo Andò, Antonio Alfieri, Francesco De Blasio

2 registry-linked trialsAbstract read
In one paragraph

Article in Multidisciplinary respiratory medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 63 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04426097 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of Cervical Vagal Blockade on Cough Incidence in Non-intubated Uniportal Video-assisted Thoracoscopic Surgery

TypeinterventionalSponsorTaipei Medical University WanFang HospitalRan2020 to 2022Enrolled40ConditionsVideo-assisted Thoracoscopic SurgeryArmsCervical Vagal Blockade, Without Blockade
NCT07524712 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Preliminary Study on the Associated Mechanisms Between Surgical Instruments and Postoperative Cough

TypeinterventionalSponsorTongji HospitalRan2026 to 2028Enrolled248ConditionsPostoperative Cough, Cough Hypersensitivity SyndromeArmsEnergy Device Vagus Nerve Transection, Mechanical Vagus Nerve Transection
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  14. Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
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  19. Role of Sensory Nerves in Pulmonary Fibrosis.International journal of molecular sciences · 2024
    Review
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mario PolverinoLung Diseases Institute, Medical Sciences Department, ASL Salerno, Viale S, Francesco, Nocera Inferiore (Salerno), Italy. mpolverino@qubisoft.it.
Francesca Polverino
Marco Fasolino
Filippo Andò
Antonio Alfieri
Francesco De Blasio

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coughing is an important defensive reflex that occurs through the stimulation of a complex reflex arc. It accounts for a significant number of consultations both at the level of general practitioner and of respiratory specialists. In this review we first analyze the cough reflex under normal conditions; then we analyze the anatomy and the neuro-pathophysiology of the cough reflex arc. The aim of this review is to provide the anatomic and pathophysiologic elements of evaluation of the complex and multiple etiologies of cough.

Identifiers

PMID22958367
PMCPMC3415124

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.