ArticleBMC genomics2012
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Microbial Oligosaccharides with Biomedical Applications.Marine drugs · 2021Review
- Activation of a Cryptic Manumycin-Type Biosynthetic Gene Cluster ofMicroorganisms · 2021Article
- Complete Genome of Nocamycin-Producing Strain Saccharothrix syringae NRRL B-16468 Reveals the Biosynthetic Potential for Secondary Metabolites.Current microbiology · 2021Article
- Targeted Genome Mining-From Compound Discovery to Biosynthetic Pathway Elucidation.Microorganisms · 2020Article
- Biosynthesis of Rhamnosylated Anthraquinones inJournal of microbiology and biotechnology · 2020Article
- Synthesis of the Non-Reducing Hexasaccharide Fragment of Saccharomicin B.Organic letters · 2018Article
- Stereospecific Synthesis of the Saccharosamine-Rhamnose-Fucose Fragment Present in Saccharomicin B.Organic letters · 2018Article
- Reagent-Controlled Synthesis of the Branched Trisaccharide Fragment of the Antibiotic Saccharomicin B.Organic letters · 2018Article
- Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5.Journal of industrial microbiology & biotechnology · 2018Article
- Gifted microbes for genome mining and natural product discovery.Journal of industrial microbiology & biotechnology · 2017Review
- Highly Active and Specific Tyrosine Ammonia-Lyases from Diverse Origins Enable Enhanced Production of Aromatic Compounds in Bacteria and Saccharomyces cerevisiae.Applied and environmental microbiology · 2015Article
- Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae.BMC genomics · 2014Article
- Bioactive oligosaccharide natural products.Natural product reports · 2014Review
- Genomic characteristics and comparative genomics analysis of Penicillium chrysogenum KF-25.BMC genomics · 2014Article
- MbtH homology codes to identify gifted microbes for genome mining.Journal of industrial microbiology & biotechnology · 2014Article
- Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis.Applied and environmental microbiology · 2013Article
- Genome analysis coupled with physiological studies reveals a diverse nitrogen metabolism in Methylocystis sp. strain SC2.PloS one · 2013Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe genus Saccharothrix is a representative of the family Pseudonocardiaceae, known to include producer strains of a wide variety of potent antibiotics. Saccharothrix espanaensis produces both saccharomicins A and B of the promising new class of heptadecaglycoside antibiotics, active against both bacteria and yeast.
resultsTo better assess its capabilities, the complete genome sequence of S. espanaensis was established. With a size of 9,360,653 bp, coding for 8,501 genes, it stands alongside other Pseudonocardiaceae with large genomes. Besides a predicted core genome of 810 genes shared in the family, S. espanaensis has a large number of accessory genes: 2,967 singletons when compared to the family, of which 1,292 have no clear orthologs in the RefSeq database. The genome analysis revealed the presence of 26 biosynthetic gene clusters potentially encoding secondary metabolites. Among them, the cluster coding for the saccharomicins could be identified.
conclusionS. espanaensis is the first completely sequenced species of the genus Saccharothrix. The genome discloses the cluster responsible for the biosynthesis of the saccharomicins, the largest oligosaccharide antibiotic currently identified. Moreover, the genome revealed 25 additional putative secondary metabolite gene clusters further suggesting the strain's potential for natural product synthesis.
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