ArticleJournal of neurodevelopmental disorders2012
Adolescents with prenatal cocaine exposure show subtle alterations in striatal surface morphology and frontal cortical volumes.
Article in Journal of neurodevelopmental disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI.Brain imaging and behavior · 2022Article
- The effect of crack cocaine addiction and age on the microstructure and morphology of the human striatum and thalamus using shape analysis and fast diffusion kurtosis imaging.Translational psychiatry · 2017Article
- Executive function and cortical thickness in youths prenatally exposed to cocaine, alcohol and tobacco.Developmental cognitive neuroscience · 2015Article
- Brain Imaging and Neurodevelopment in HIV-uninfected Thai Children Born to HIV-infected Mothers.The Pediatric infectious disease journal · 2015Article
- Apolipoprotein E epsilon 4 allele is associated with ventricular expansion rate and surface morphology in dementia and normal aging.Neurobiology of aging · 2014Article
- Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Structural brain imaging in children and adolescents following prenatal cocaine exposure: preliminary longitudinal findings.Developmental neuroscience · 2014Article
- Developmental origins of brain disorders: roles for dopamine.Frontiers in cellular neuroscience · 2013Review
- Prenatal drug exposure and executive function in early adolescence.Neurotoxicology and teratologyArticle
- Longitudinal changes of amygdala and default mode activation in adolescents prenatally exposed to cocaine.Neurotoxicology and teratologyArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPublished structural neuroimaging studies of prenatal cocaine exposure (PCE) in humans have yielded somewhat inconsistent results, with several studies reporting no significant differences in brain structure between exposed subjects and controls. Here, we sought to clarify some of these discrepancies by applying methodologies that allow for the detection of subtle alterations in brain structure.
methodsWe applied surface-based anatomical modeling methods to magnetic resonance imaging (MRI) data to examine regional changes in the shape and volume of the caudate and putamen in adolescents with prenatal cocaine exposure (n = 40, including 28 exposed participants and 12 unexposed controls, age range 14 to 16 years). We also sought to determine whether changes in regional brain volumes in frontal and subcortical regions occurred in adolescents with PCE compared to control participants.
resultsThe overall volumes of the caudate and putamen did not significantly differ between PCE participants and controls. However, we found significant (P <0.05, uncorrected) effects of levels of prenatal exposure to cocaine on regional patterns of striatal morphology. Higher levels of prenatal cocaine exposure were associated with expansion of certain striatal subregions and with contraction in others. Volumetric analyses revealed no significant changes in the volume of any subcortical region of interest, but there were subtle group differences in the volumes of some frontal cortical regions, in particular reduced volumes of caudal middle frontal cortices and left lateral orbitofrontal cortex in exposed participants compared to controls.
conclusionsPrenatal cocaine exposure may lead to subtle and regionally specific patterns of regional dysmorphology in the striatum and volumetric changes in the frontal lobes. The localized and bidirectional nature of effects may explain in part the contradictions in the existing literature.
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