ArticleCancer science2012
Nuclear receptor coactivator RAC3 inhibits autophagy.
Article in Cancer science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- NCoA3 upregulation in breast cancer‑associated adipocytes elicits an inflammatory profile.Oncology reports · 2023Article
- The landscape and prognostic value of immune characteristics in uterine corpus endometrial cancer.Bioscience reports · 2021Article
- Autophagy and Cancer Dormancy.Frontiers in oncology · 2021Review
- High RAC3 expression levels are required for induction and maintaining of cancer cell stemness.Oncotarget · 2018Article
- Role of RAC3 coactivator in the adipocyte differentiation.Cell death discovery · 2018Article
- The inflammatory cytokine TNF contributes with RAC3-induced malignant transformation.EXCLI journal · 2018Article
- RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition.Cancer cell international · 2017Article
- RAC3 more than a nuclear receptor coactivator: a key inhibitor of senescence that is downregulated in aging.Cell death & disease · 2015Article
- The levels of RAC3 expression are up regulated by TNF in the inflammatory response.FEBS open bio · 2014Article
- Nuclear receptor coactivator RAC3 inhibits autophagy.Cancer science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RAC3 is an oncogene naturally overexpressed in several tumors. Besides its role as coactivator, it can exert several protumoral cytoplasmic actions. Autophagy was found to act either as a tumor suppressor during the early stages of tumor development, or as a protector of the tumor cell in later stages under hypoxic conditions. We found that RAC3 overexpression inhibits autophagy when induced by starvation or rapamycin and involves RAC3 nuclear translocation-dependent and -independent mechanisms. Moreover, hypoxia inhibits the RAC3 gene expression leading to the autophagy process, allowing tumor cells to survive until angiogenesis occurs. The interplay between RAC3, hypoxia, and autophagy could be an important mechanism for tumor progression and a good target for a future anticancer therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.