ArticleInternational journal of evolutionary biology2012
Positive Selection and the Evolution of izumo Genes in Mammals.
Article in International journal of evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Recurrent Duplication and Diversification of Acrosomal Fertilization Proteins in Abalone.Frontiers in cell and developmental biology · 2022Article
- The Importance of Gene Duplication and Domain Repeat Expansion for the Function and Evolution of Fertilization Proteins.Frontiers in cell and developmental biology · 2022Review
- Sperm lacking Bindin are infertile but are otherwise indistinguishable from wildtype sperm.Scientific reports · 2021Article
- Evolutionary, proteomic, and experimental investigations suggest the extracellular matrix of cumulus cells mediates fertilization outcomes†.Biology of reproduction · 2021Article
- Expression, structure and function analysis of the sperm-oocyte fusion genes Juno and Izumo1 in sheep (Ovis aries).Journal of animal science and biotechnology · 2021Article
- Genetic diversity in the IZUMO1-JUNO protein-receptor pair involved in human reproduction.PloS one · 2021Article
- Expression Analysis ofAnimals : an open access journal from MDPI · 2019Article
- Egg Coat Proteins Across Metazoan Evolution.Current topics in developmental biology · 2018Review
- New Genes and Functional Innovation in Mammals.Genome biology and evolution · 2017Article
- Article
- Izumo1 and Juno: the evolutionary origins and coevolution of essential sperm-egg binding partners.Royal Society open science · 2015Article
- Vaccine for human contraception targeting sperm Izumo protein and YLP12 dodecamer peptide.Protein science : a publication of the Protein Society · 2014Review
- Sperm-egg fusion: a molecular enigma of mammalian reproduction.International journal of molecular sciences · 2014Review
- Detecting coevolution in mammalian sperm-egg fusion proteins.Molecular reproduction and development · 2014Article
- Critical role of exosomes in sperm-egg fusion and virus-induced cell-cell fusion.Reproductive medicine and biology · 2013Review
- Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations.BMC evolutionary biology · 2013Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most genes linked to male reproductive function have been known to evolve rapidly among species and to show signatures of positive selection. Different male species-specific reproductive strategies have been proposed to underlie positive selection, such as sperm competitive advantage and control over females postmating physiology. However, an underexplored aspect potentially affecting male reproductive gene evolution in mammals is the effect of gene duplications. Here we analyze the molecular evolution of members of the izumo gene family in mammals, a family of four genes mostly expressed in the sperm with known and potential roles in sperm-egg fusion. We confirm a previously reported bout of selection for izumo1 and establish that the bout of selection is restricted to the diversification of species of the superorder Laurasiatheria. None of the izumo genes showed evidence of positive selection in Glires (Rodentia and Lagomorpha), and in the case of the non-testes-specific izumo4, rapid evolution was driven by relaxed selection. We detected evidence of positive selection for izumo3 among Primates. Interestingly, positively selected sites include several serine residues suggesting modifications in protein function and/or localization among Primates. Our results suggest that positive selection is driven by aspects related to species-specific adaptations to fertilization rather than sexual selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.