ArticleEpilepsy research and treatment2012
Depression in temporal lobe epilepsy: a review of prevalence, clinical features, and management considerations.
Article in Epilepsy research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 64 citations in OpenAlex.
- Detrended fluctuation analysis of amygdala-hippocampal beta synchrony reveals network rigidity in depression associated with temporal lobe epilepsy.Journal of neural engineering · 2026Article
- Influence of Epilepsy Characteristics on the Anxiety Occurrence.Brain sciences · 2024Article
- Article
- Management of anhedonia after epilepsy surgery.Epilepsy & behavior reports · 2024Article
- Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy.Frontiers in neuroscience · 2024Article
- Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence.Neuropharmacology · 2023Review
- An exploratory study of brain temperature and choline abnormalities in temporal lobe epilepsy patients with depressive symptoms.Epilepsia open · 2023Article
- Screening of Major Depression Disorder in Patients With Epilepsy in Indonesian National Referral Hospital.Neurology. Clinical practice · 2023Article
- Long-term serotonin abnormalities in the brain of immature rats subjected to febrile seizures.Iranian journal of basic medical sciences · 2023Article
- [No fear of anything: epilepsy, psychiatric comorbidity and surgery. A clinical case report].Revista de neurologia · 2022Article
- Review
- Recall and Self-Relevance of Emotional Words Predict Subjective Self-Evaluation of Cognition in Patients with MTLE with or without Depressive Symptoms.Brain sciences · 2021Article
- Psychological comorbidities in epilepsy: a cross-sectional survey among Ghanaian epilepsy patients.Ghana medical journal · 2021Article
- Article
- Depressive disorders in patients with pharmaco-resistant mesial temporal lobe epilepsy.The Journal of international medical research · 2018Article
- Protective Effect of Nerolidol Against Pentylenetetrazol-Induced Kindling, Oxidative Stress and Associated Behavioral Comorbidities in Mice.Neurochemical research · 2016Article
- Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs.Frontiers in neuroscience · 2016Review
- Frontolimbic brain networks predict depressive symptoms in temporal lobe epilepsy.Epilepsy research · 2014Article
- Synthesis of a FTO inhibitor with anticonvulsant activity.ACS chemical neuroscience · 2014Article
- Alterations in functional connectivity between the hippocampus and prefrontal cortex as a correlate of depressive symptoms in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression in temporal lobe epilepsy has been established as a frequent occurrence, and various possible mechanisms for this significant comorbidity have been posited. However, there is still little to guide a clinician in the recognition and management of depression in patients with temporal lobe epilepsy. This is in part due to the lack of consistent findings in earlier studies, which was likely partly due to variabilities in methodology, sampling, and diagnosis of both temporal lobe epilepsy and depression. However, in recent years, significant effort has been made to address these issues and provide a framework for diagnosis and management of depression in this population. The following is a review of the literature, with special emphasis on clinical phenomenology of depressive symptoms, described bidirectional risk between depression and temporal lobe epilepsy, and treatment strategies in the context of potential drug interactions with antiepileptic drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.