ArticlePloS one2012
Candidate polymorphisms and severe malaria in a Malian population.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Insights into Neutrophil Dysfunction in Inherited Metabolic Disorders.Journal of innate immunity · 2026Review
- Article
- High-dimensional supervised classification in a context of non-independence of observations to identify the determining SNPs in a phenotype.Infectious Disease Modelling · 2023Article
- Non-O ABO blood group genotypes differ in their associations with Plasmodium falciparum rosetting and severe malaria.PLoS genetics · 2023Article
- Genome-wide association study of leprosy in Malawi and Mali.PLoS pathogens · 2022Article
- Risk score prediction model based on single nucleotide polymorphism for predicting malaria: a machine learning approach.BMC bioinformatics · 2022Article
- Leveraging Mann-Whitney U test on large-scale genetic variation data for analysing malaria genetic markers.Malaria journal · 2022Article
- Article
- Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity.Malaria journal · 2021Article
- Two complement receptor one alleles have opposing associations with cerebral malaria and interact with αeLife · 2018Article
- Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease.Scientific reports · 2018Article
- The Contribution of Co-signaling Pathways to Anti-malarial T Cell Immunity.Frontiers in immunology · 2018Review
- Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study.PloS one · 2018Article
- Host factors that modify Plasmodium falciparum adhesion to endothelial receptors.Scientific reports · 2017Article
- Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.G3 (Bethesda, Md.) · 2017Article
- Prevalence of polymorphisms in glucose-6-phosphate dehydrogenase, sickle haemoglobin and nitric oxide synthase genes and their relationship with incidence of uncomplicated malaria in Iganga, Uganda.Malaria journal · 2017Article
- Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.eLife · 2017Article
- Relationship between Malaria and ABO Blood Types in East China.BioMed research international · 2017Article
- Geographical distribution of complement receptor type 1 variants and their associated disease risk.PloS one · 2017Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity. We assess the influence of sixty-four candidate loci, including the sickle cell polymorphism (HbS), on severe malaria in a case-control study consisting of over 900 individuals from Bamako, Mali. We confirm the known protective effects of the blood group O and the HbS AS genotype on life-threatening malaria. In addition, our analysis revealed a marginal susceptibility effect for the CD40 ligand (CD40L)+220C allele. The lack of statistical evidence for other candidates may demonstrate the need for large-scale genome-wide association studies in malaria to discover new polymorphisms. It also demonstrates the need for establishing the region-specific repertoire of functional variation in important genes, including the glucose-6-phosphatase deficiency gene, before embarking on focused genotyping.
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