ArticleCellular and molecular bioengineering2010
Influence of Transmural Pressure and Cytoskeletal Structure on NF-κB Activation in Respiratory Epithelial Cells.
Article in Cellular and molecular bioengineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Hic-5 drives epithelial mechanotransduction promoting a feed-forward cycle of bronchoconstriction.Nature communications · 2025Article
- Magnetoactive,Cellular and molecular bioengineering · 2024Article
- Article
- Mechanobiology of Pulmonary Diseases: A Review of Engineering Tools to Understand Lung Mechanotransduction.Journal of biomechanical engineering · 2021Review
- mTORC1 is a mechanosensor that regulates surfactant function and lung compliance during ventilator-induced lung injury.JCI insight · 2021Article
- Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation.Nature communications · 2021Article
- An Overview of the Role of Mechanical Stretching in the Progression of Lung Cancer.Frontiers in cell and developmental biology · 2021Review
- The Aftermath of Bronchoconstriction.Journal of engineering and science in medical diagnostics and therapy · 2019Review
- Wnt Signaling: Pathogen Incursion and Immune Defense.Frontiers in immunology · 2019Review
- Using a Novel Microfabricated Model of the Alveolar-Capillary Barrier to Investigate the Effect of Matrix Structure on Atelectrauma.Scientific reports · 2017Article
- Simvastatin Treatment Modulates Mechanically-Induced Injury and Inflammation in Respiratory Epithelial Cells.Annals of biomedical engineering · 2016Article
- Cell Jamming in the Airway Epithelium.Annals of the American Thoracic Society · 2016Review
- Putting the Squeeze on Airway Epithelia.Physiology (Bethesda, Md.) · 2015Review
- Influence of airway wall compliance on epithelial cell injury and adhesion during interfacial flows.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Computational analysis of microbubble flows in bifurcating airways: role of gravity, inertia, and surface tension.Journal of biomechanical engineering · 2014Article
- Animal models of ex vivo lung perfusion as a platform for transplantation research.World journal of experimental medicine · 2014Review
- Fibers in the extracellular matrix enable long-range stress transmission between cells.Biophysical journal · 2013Article
- Article
- miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration.American journal of physiology. Lung cellular and molecular physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Respiratory epithelial cells are exposed to complex mechanical forces which are often modulated during pathological conditions such as Otitis Media and acute lung injury. The transduction of these mechanical forces into altered inflammatory signaling may play an important role in the persistence of disease conditions and inflammation. In this study, we investigated how static and oscillatory pressures altered the activation of NF-κB inflammatory pathways and how changes in the actin cytoskeleton influenced the mechanotransduction of pressure into NF-κB activation. An in vitro system was used to apply static and oscillatory pressures to alveolar epithelial cells cultured at an air-liquid interface. Latrunculin A and Jasplakinolide were used to alter the cytoskeleton and tight-junction structure and ELISA was used to monitor activation of NF-κB. Results indicate that both static and oscillatory pressures can activate NF-κB and that this activation is magnitude-dependent at low oscillation frequencies only. Jasplakinolide treated cells did not exhibit significant changes in normalized NF-κB activation compared to unloaded controls while Latrunculin treated cells exhibited increases in normalized NF-κB activation only at low frequency or static pressures. These results indicate that altering the actin cytoskeleton may be a useful way to mitigate the mechanotransduction of pressure forces into inflammatory signaling.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.