Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
A neural signature of affiliative emotion in the human septohypothalamic area.
Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional neuroimaging of the human lateral septum: a systematic review of behavioral correlates and anatomical localization.Social cognitive and affective neuroscience · 2026Pooled it
- Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis.Neuroscience and biobehavioral reviews · 2023Pooled it
- The neuroscience of social feelings: mechanisms of adaptive social functioning.Neuroscience and biobehavioral reviews · 2021Pooled it
- Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species.iScience · 2025Article
- GABA receptor antagonism elicits feeding in the septohypothalamic nucleus.Frontiers in behavioral neuroscience · 2025Article
- Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species.bioRxiv : the preprint server for biology · 2024Article
- Age-related decline in social interaction is associated with decreasedAging brain · 2024Article
- Article
- Beyond shallow feelings of complex affect: Non-motor correlates of subjective emotional experience in Parkinson's disease.PloS one · 2023Article
- Functional Neuroimaging of Human Hypothalamus in Socioemotional Behavior: A Systematic Review.Brain sciences · 2022Review
- Neural Correlates of Listening to Varying Synchrony Between Beats in Samba Percussion and Relations to Feeling the Groove.Frontiers in neuroscience · 2022Article
- Article
- Systems Neuroscience of Natural Behaviors in Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Classification of Complex Emotions Using EEG and Virtual Environment: Proof of Concept and Therapeutic Implication.Frontiers in human neuroscience · 2021Article
- Activation in bed nucleus of the stria terminalis (BNST) corresponds to everyday helping.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Positive affect between close friends: Brain-behavior associations during adolescence.Social neuroscience · 2020Article
- Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020Article
- Article
- Asymmetric hemisphere activation in tenderness: evidence from EEG signals.Scientific reports · 2018Article
- Emotion Regulation Using Virtual Environments and Real-Time fMRI Neurofeedback.Frontiers in neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Comparative studies have established that a number of structures within the rostromedial basal forebrain are critical for affiliative behaviors and social attachment. Lesion and neuroimaging studies concur with the importance of these regions for attachment and the experience of affiliation in humans as well. Yet it remains obscure whether the neural bases of affiliative experiences can be differentiated from the emotional valence with which they are inextricably associated at the experiential level. Here we show, using functional MRI, that kinship-related social scenarios evocative of affiliative emotion induce septal-preoptic-anterior hypothalamic activity that cannot be explained by positive or negative emotional valence alone. Our findings suggest that a phylogenetically conserved ensemble of basal forebrain structures, especially the septohypothalamic area, may play a key role in enabling human affiliative emotion. Our finding of a neural signature of human affiliative experience bears direct implications for the neurobiological mechanisms underpinning impaired affiliative experiences and behaviors in neuropsychiatric conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.