ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 120 papers.
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120 citing papers in PubMed, 255 citations in OpenAlex.
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- Drosophila melanogaster larvae generate force to counteract external mechanical pressure.The Journal of experimental biology · 2026Article
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- Tonically active interneurons gate motor output inbioRxiv : the preprint server for biology · 2026Article
- Beyond locomotion: How specialized motor patterns enable a vertebrate to struggle free from capture.iScience · 2025Article
- Finding a path: local search behavior of Drosophila larvae.The Journal of experimental biology · 2025Article
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- Neural substrates of cold nociception ineLife · 2025Article
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- Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sensation of electric fields in the Drosophila melanogaster larva.Current biology : CB · 2025Article
- Characterizing stage-dependent neuromotor patterns inFrontiers in neuroscience · 2025Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Understanding rhythmic behavior at the developmental and genetic levels has important implications for neurobiology, medicine, evolution, and robotics. We studied rhythmic behavior--larval crawling--in the genetically and developmentally tractable organism, Drosophila melanogaster. We used narrow-diameter channels to constrain behavior to simple, rhythmic crawling. We quantified crawling at the organism, segment, and muscle levels. We showed that Drosophila larval crawling is made up of a series of periodic strides. Each stride consists of two phases. First, while most abdominal segments remain planted on the substrate, the head, tail, and gut translocate; this "visceral pistoning" moves the center of mass. The movement of the center of mass is likely powered by muscle contractions in the head and tail. Second, the head and tail anchor while a body wall wave moves each abdominal segment in the direction of the crawl. These two phases can be observed occurring independently in embryonic stages before becoming coordinated at hatching. During forward crawls, abdominal body wall movements are powered by simultaneous contraction of dorsal and ventral muscle groups, which occur concurrently with contraction of lateral muscles of the adjacent posterior segment. During reverse crawls, abdominal body wall movements are powered by phase-shifted contractions of dorsal and ventral muscles; and ventral muscle contractions occur concurrently with contraction of lateral muscles in the adjacent anterior segment. This work lays a foundation for use of Drosophila larva as a model system for studying the genetics and development of rhythmic behavior.
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