Narcolepsy: neural mechanisms of sleepiness and cataplexy.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

55 citing papers in PubMed.

1. Time to Onset of Response to Pitolisant for the Treatment of Excessive Daytime Sleepiness and Cataplexy in Patients With Narcolepsy: An Analysis of Randomized, Placebo-Controlled Trials.CNS drugs · 2021
   Trial
2. The role of histamine in narcolepsy type 1: a narrative review.Frontiers in neurology · 2026
   Review
3. Vitamin D and Sleep Disorders.Advances in experimental medicine and biology · 2026
   Review
4. Narcolepsy as an immune-associated hypothalamic encephalopathy: orexin dysfunction and implications for precision sleep medicine.Frontiers in psychiatry · 2026
   Review
5. Synchrony of neuromodulatory systems during NREM sleep.Proceedings of the National Academy of Sciences of the United States of America · 2025
   Article
6. The role of orexin and MCH neurons in the hypothalamus in sleep-wake regulation and learning-forgetting balance.Frontiers in neuroscience · 2025
   Review
7. The Role and Mechanisms of the Hypocretin System in Zebrafish (International journal of molecular sciences · 2024
   Review
8. Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.Nature communications · 2024
   Article
9. A Dynamic Foundation: Aberrations of Sleep Architecture and Its Association With Clinical and Sub-clinical Psychopathology.Cureus · 2024
   Review
10. Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control.Molecular psychiatry · 2024
    Article
11. Deficiency of orexin signaling during sleep is involved in abnormal REM sleep architecture in narcolepsy.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
12. Dopamine release in the nucleus accumbens promotes REM sleep and cataplexy.iScience · 2023
    Article
13. The melanin-concentrating hormone system as a target for the treatment of sleep disorders.Frontiers in neuroscience · 2022
    Review
14. Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022
    Article
15. Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation.Psychopharmacology · 2021
    Article
16. Mapping Network Activity in Sleep.Frontiers in neuroscience · 2021
    Review
17. Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings.Current neurology and neuroscience reports · 2020
    Review
18. A circuit perspective on narcolepsy.Sleep · 2020
    Article
19. Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy.eLife · 2020
    Article
20. Perampanel-Induced Cataplexy in a Young Male with Generalized Epilepsy.HCA healthcare journal of medicine · 2020
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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