ArticleMolecular biology of the cell2012
The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
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- Citrate trafficking supports rewiring of mitochondrial metabolism via RTG signaling in yeast osmoadaptation.The Biochemical journal · 2025Article
- The Viral K1 Killer Yeast System: Toxicity, Immunity, and Resistance.Yeast (Chichester, England) · 2024Review
- Regulation of Catalase Expression and Activity byJournal of fungi (Basel, Switzerland) · 2024Article
- A Matlab-based application for quantification of yeast cell growth on solid media.Journal of the Royal Society, Interface · 2024Article
- Organelle Communication with the Nucleus.Results and problems in cell differentiation · 2024Review
- Host-derived reactive oxygen species trigger activation of the Candida albicans transcription regulator Rtg1/3.PLoS pathogens · 2023Article
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- Nuclear Functions of KaeA, a Subunit of the KEOPS Complex inInternational journal of molecular sciences · 2022Article
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- Role of spt23 in Saccharomyces cerevisiae thermal tolerance.Applied microbiology and biotechnology · 2022Article
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- Novel interconnections of HOG signaling revealed by combined use of two proteomic software packages.Cell communication and signaling : CCS · 2019Article
- Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment.Cells · 2019Review
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- Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death throughOxidative medicine and cellular longevity · 2019Article
- Mitochondria-cytosol-nucleus crosstalk: learning from Saccharomyces cerevisiae.FEMS yeast research · 2018Review
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Authors and funding
5 authors.
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Abstract
Cells modulate expression of nuclear genes in response to alterations in mitochondrial function, a response termed retrograde (RTG) regulation. In budding yeast, the RTG pathway relies on Rtg1 and Rtg3 basic helix-loop-helix leucine Zipper transcription factors. Exposure of yeast to external hyperosmolarity activates the Hog1 stress-activated protein kinase (SAPK), which is a key player in the regulation of gene expression upon stress. Several transcription factors, including Sko1, Hot1, the redundant Msn2 and Msn4, and Smp1, have been shown to be directly controlled by the Hog1 SAPK. The mechanisms by which Hog1 regulates their activity differ from one to another. In this paper, we show that Rtg1 and Rtg3 transcription factors are new targets of the Hog1 SAPK. In response to osmostress, RTG-dependent genes are induced in a Hog1-dependent manner, and Hog1 is required for Rtg1/3 complex nuclear accumulation. In addition, Hog1 activity regulates Rtg1/3 binding to chromatin and transcriptional activity. Therefore Hog1 modulates Rtg1/3 complex activity by multiple mechanisms in response to stress. Overall our data suggest that Hog1, through activation of the RTG pathway, contributes to ensure mitochondrial function as part of the Hog1-mediated osmoadaptive response.
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