Evidence map›Paper›PMID 22956631›Full record

ArticleToxicological sciences : an official journal of the Society of Toxicology2013

PPTOX III: environmental stressors in the developmental origins of disease--evidence and mechanisms.

Thaddeus T Schug, Robert Barouki, Peter D Gluckman, Philippe Grandjean, Mark Hanson, Jerold J Heindel

Abstract readConference Proceedings
In one paragraph

Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
    Article
  9. Article
  10. Multigenerational and Transgenerational Effects of Dioxins.International journal of molecular sciences · 2019
    Review
  11. Article
  12. Review
  13. Making Waves: New Developments in Toxicology With the Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2018
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Evolution of DOHaD: the impact of environmental health sciences.Journal of developmental origins of health and disease · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thaddeus T SchugDivision of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. schugt@niehs.nih.gov
Robert Barouki
Peter D Gluckman
Philippe Grandjean
Mark Hanson
Jerold J Heindel

Funding

PPTOX III: Environmental Stressors in the Developmental Origins of Disease: EvideR13HD072606 · NICHD · SOCIETY OF TOXICOLOGY · PI WALKER, CHERYL L. · 2012 to 2012
$6k
NICHD NIH HHS R13 HD072606
6 · The paper itself

Abstract

Fetal and early postnatal development constitutes the most vulnerable time period of human life in regard to adverse effects of environmental hazards. Subtle effects during development can lead to functional deficits and increased disease risk later in life. The hypothesis stating that environmental exposures leads to altered programming and, thereby, to increased susceptibility to disease or dysfunction later in life has garnered much support from both experimental and epidemiological studies. Similar observations have been made on the long-term impact of nutritional unbalance during early development. In an effort to bridge the fields of nutritional and environmental developmental toxicity, the Society of Toxicology sponsored this work. This report summarizes novel findings in developmental toxicity as reported by select invited experts and meeting attendees. Recommendations for the application and improvement of current and future research efforts are also presented.

Indexed as

Environmental ExposureAnimalsDiseaseEpigenesis, GeneticGene ExpressionHumansImmune SystemRisk Factors

Identifiers

PMID22956631
PMCPMC3551422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.