ArticleInvestigative ophthalmology & visual science2012
Human lamina cribrosa insertion and age.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina.Investigative ophthalmology & visual science · 2024Article
- Fibrous finite element modeling of the optic nerve head region.Acta biomaterialia · 2024Article
- Deep Optic Nerve Head Morphology in Tilted Disc Syndrome and Its Clinical Implication on Visual Damage.Investigative ophthalmology & visual science · 2023Article
- Lamina cribrosa vessel and collagen beam networks are distinct.Experimental eye research · 2022Article
- Quantification of collagen fiber structure using second harmonic generation imaging and two-dimensional discrete Fourier transform analysis: Application to the human optic nerve head.Journal of biophotonics · 2019Article
- Regional Deformation of the Optic Nerve Head and Peripapillary Sclera During IOP Elevation.Investigative ophthalmology & visual science · 2018Article
- Seeing the Hidden Lamina: Effects of Exsanguination on the Optic Nerve Head.Investigative ophthalmology & visual science · 2018Article
- Age related changes of the central lamina cribrosa thickness, depth and prelaminar tissue in healthy Chinese subjects.International journal of ophthalmology · 2018Article
- A Digital Staining Algorithm for Optical Coherence Tomography Images of the Optic Nerve Head.Translational vision science & technology · 2017Article
- Collagen Architecture of the Posterior Pole: High-Resolution Wide Field of View Visualization and Analysis Using Polarized Light Microscopy.Investigative ophthalmology & visual science · 2017Article
- Comparative Anatomy of the Trabecular Meshwork, the Optic Nerve Head and the Inner Retina in Rodent and Primate Models Used for Glaucoma Research.Vision (Basel, Switzerland) · 2016Review
- Translating ocular biomechanics into clinical practice: current state and future prospects.Current eye research · 2015Review
- Article
- Application of Elliptic Fourier analysis to describe the lamina cribrosa shape with age and intraocular pressure.Experimental eye research · 2014Article
- Eye-specific IOP-induced displacements and deformations of human lamina cribrosa.Investigative ophthalmology & visual science · 2014Article
- In vivo optic nerve head biomechanics: performance testing of a three-dimensional tracking algorithm.Journal of the Royal Society, Interface · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo test the hypothesis that in healthy human eyes the lamina cribrosa (LC) insertion into the pia mater increases with age.
methodsThe optic nerve heads (ONHs) of donor eyes fixed at either 5 or 50 mm Hg of IOP were sectioned, stained, and imaged under bright- and dark-field conditions. A 3-dimensional (3D) model of each ONH was reconstructed. From the 3D models we measured the area of LC insertion into the peripapillary scleral flange and into the pia, and computed the total area of insertion and fraction of LC inserting into the pia. Linear mixed effect models were used to determine if the measurements were associated with age or IOP.
resultsWe analyzed 21 eyes from 11 individuals between 47 and 91 years old. The LC inserted into the pia in all eyes. The fraction of LC inserting into the pia (2.2%-29.6%) had a significant decrease with age (P = 0.049), which resulted from a nonsignificant increase in the total area of LC insertion (P = 0.41) and a nonsignificant decrease in the area of LC insertion into the pia (P = 0.55). None of the measures was associated with fixation IOP (P values 0.44-0.81). Differences between fellow eyes were smaller than differences between unrelated eyes.
conclusionsThe LC insertion into the pia mater is common in middle-aged and older eyes, and does not increase with age. The biomechanical and vascular implications of the LC insertion into the pia mater are not well understood and should be investigated further.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.