ArticleThe oncologist2012
The role of lung metastasis resection in improving outcome of colorectal cancer patients: results from a large retrospective study.
Article in The oncologist, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multimodal treatment improves survival in patients with lung metastases from colorectal cancer: A network meta-analysis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Pooled it
- Does adjuvant chemotherapy improve the prognosis of patients after resection of pulmonary metastasis from colorectal cancer? A systematic review and meta-analysis.International journal of colorectal disease · 2019Pooled it
- Survival differences with immediate versus delayed chemotherapy for asymptomatic incurable metastatic colorectal cancer.The Cochrane database of systematic reviews · 2018Pooled it
- Article
- Long-Term Results of Multiple Pulmonary Metastasectomies.Annals of surgical oncology · 2026Article
- Neoadjuvant therapy for resectable colorectal cancer pulmonary oligometastases: a retrospective cohort study.International journal of colorectal disease · 2025Article
- A pelvis MR transformer-based deep learning model for predicting lung metastases risk in patients with rectal cancer.Frontiers in oncology · 2025Article
- Decoding colorectal cancer lung metastasis: a global research odyssey.Frontiers in oncology · 2025Article
- A Retrospective Analysis of Real-Life Management of Colorectal Cancer Lung-Limited Metastases Treated with Surgery: Outcomes and Prognostic Factors.Journal of clinical medicine · 2024Article
- Survival outcome following surgical versus non-surgical treatment of colorectal lung metastasis-a retrospective cohort study.Langenbeck's archives of surgery · 2024Article
- Review
- CT-guided radioactiveBMC cancer · 2024Article
- High Yield of Chest X-ray in the Follow-Up of Colorectal Cancer.Journal of clinical medicine · 2022Article
- Homogeneous and heterogeneous risk and prognostic factors for lung metastasis in colorectal cancer patients.BMC gastroenterology · 2022Article
- Management of single pulmonary metastases from colorectal cancer: State of the art.World journal of gastrointestinal oncology · 2022Review
- Long-term outcome following microwave ablation of lung metastases from colorectal cancer.Frontiers in oncology · 2022Article
- Efficacy of adjuvant chemotherapy after complete resection of pulmonary metastasis from colorectal cancer.Molecular and clinical oncology · 2021Article
- National variation in pulmonary metastasectomy for colorectal cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- Genetic differences between lung metastases and liver metastases from left-sided microsatellite stable colorectal cancer: next generation sequencing and clinical implications.Annals of translational medicine · 2021Article
- An Exploratory Study on the Stable Radiomics Features of Metastatic Small Pulmonary Nodules in Colorectal Cancer Patients.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of surgery for lung metastases (LM) secondary to colorectal cancer (CRC) remains controversial. The bulk of evidence is derived from single surgical series, hampering any definitive conclusions. The aim of this study was to compare the outcomes of CRC patients with LM submitted to surgery with those who were not. PATIENTS AND
methodsData from 409 patients with LM as the first evidence of advanced disease were extracted from a database of 1,411 patients. Patients were divided into three groups: G1, comprised of 155 patients with pulmonary and extrapulmonary metastases; G2, comprised of 104 patients with LM only and no surgery; G3, comprised of 50 patients with LM only and submitted to surgery.
resultsNo difference in response rates emerged between G1 and G2. Median progression-free survival (PFS) times were: 10.3 months, 10.5 months, and 26.2 months for G1, G2, and G3, respectively. No difference in PFS times was observed between G1 and G2, whereas there was a statistically significant difference between G2 and G3. Median overall survival times were 24.2 months, 31.5 months, and 72.4 months, respectively. Survival times were longer in resected patients: 17 survived >5 years and three survived >10 years. In patients with LM only and no surgery, four survived for 5 years and none survived >10 years.
conclusionsEven though patients with resectable LM are more likely to be those with a better outcome, our study provides evidence suggesting an active role of surgery in improving survival outcomes in this patient subset.
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