ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2013
Implementation of modified early-goal directed therapy for sepsis in the emergency center of a comprehensive cancer center.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Consensus statement for cancer patients requiring intensive care support.Annals of hematology · 2018Guideline
- Physiological changes after fluid bolus therapy in sepsis: a systematic review of contemporary data.Critical care (London, England) · 2014Pooled it
- Effects of Pharmacist-Led Clinical Pathway/Order Sets on Cancer Patients: A Systematic Review.Frontiers in pharmacology · 2021Article
- Critically ill patients with cancer: A clinical perspective.World journal of clinical oncology · 2020Review
- Importance of Pharmacy Involvement in the Treatment of Sepsis.Hospital pharmacy · 2017Article
- Early management of sepsis with emphasis on early goal directed therapy: AME evidence series 002.Journal of thoracic disease · 2017Review
- Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE.Critical care (London, England) · 2016Review
- Comparison of diagnostic and prognostic utility of lactate and procalcitonin for sepsis in adult cancer patients presenting to emergency department with systemic inflammatory response syndrome.Turkish journal of emergency medicine · 2016Article
- Critically ill patients with cancer: chances and limitations of intensive care medicine-a narrative review.ESMO open · 2016Review
- Identification of the severe sepsis patient at triage: a prospective analysis of the Australasian Triage Scale.Emergency medicine journal : EMJ · 2015Observational
- [Cancer patients in the intensive care unit. Goals of therapy, ethics, and palliation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe investigation examines the impact of a standardized sepsis order set and algorithm utilizing non-invasive monitoring for early-goal directed therapy (EGDT) in an emergency center setting on the clinical outcomes of sepsis in cancer patients.
methodsSingle-center, retrospective study comparing clinical outcomes of sepsis before and after routine usage of a standardized order set and algorithm for non-invasive elements of EGDT for sepsis in an emergency center of a comprehensive cancer center. The outcomes measures evaluated were 28-day in-hospital mortality, intensive care unit length of stay, hospital length of stay, goal mean arterial pressure and urine output within the first 6 h of treatment, time to measurement of lactic acid, and appropriateness and timeliness of initial antibiotic therapy.
resultsThe 28-day in-hospital mortality was significantly lower in the post-intervention group compared to the pre-intervention group (20 vs. 38%, p = 0.005). The percentages of patients who reached their goal mean arterial pressure (74 vs. 90%, p = 0.004) and goal urine output (79 vs. 96%, p = 0.002) during the first 6 h of treatment were higher the after than the before group. No significant differences were detected in the rest of the outcome measures.
conclusionsImplementation of a standardized sepsis order set and algorithm to improve compliance with the non-invasive elements of EGDT for sepsis in cancer patients in the emergency center setting was associated with a decreased 28-day in-hospital mortality rate.
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Registered trials
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