ArticleCirculation2012
Cardiomyogenesis in the aging and failing human heart.
Article in Circulation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 128 citations in OpenAlex.
- Endocrine Influence on Cardiac Metabolism in Development and Regeneration.Endocrinology · 2021Review
- The "Angiogenic Switch" and Functional Resources in Cyclic Sports Athletes.International journal of molecular sciences · 2021Review
- Effects of Cardiotoxins on Cardiac Stem and Progenitor Cell Populations.Frontiers in cardiovascular medicine · 2021Review
- Regenerating the field of cardiovascular cell therapy.Nature biotechnology · 2019Review
- Chasing c-Kit through the heart: Taking a broader view.Pharmacological research · 2018Review
- Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications.Cellular and molecular life sciences : CMLS · 2017Review
- Characterization and analysis of long non-coding rna (lncRNA) in In Vitro- and Ex Vivo-derived cardiac progenitor cells.PloS one · 2017Article
- Altered expression ofAmerican journal of cardiovascular disease · 2017Article
- Internal associations and dynamic expression of c-kit and nanog genes in ventricular remodelling induced by adriamycin.Experimental and therapeutic medicine · 2016Article
- Review
- Cardiomyocyte loss is not required for the progression of left ventricular hypertrophy induced by pressure overload in female mice.Journal of anatomy · 2016Article
- Mesenchymal stem cells in regenerative rehabilitation.Journal of physical therapy science · 2016Review
- Hippo/Yap Signaling in Cardiac Development and Regeneration.Current treatment options in cardiovascular medicine · 2016Review
- Cardiac Regeneration and Stem Cells.Physiological reviews · 2015Review
- Cardiac regeneration in children.Pediatric cardiology · 2015Review
- Blockade of EMAP II protects cardiac function after chronic myocardial infarction by inducing angiogenesis.Journal of molecular and cellular cardiology · 2015Article
- Cardiac stem cells: biology and clinical applications.Antioxidants & redox signaling · 2014Review
- The number of cardiac myocytes in the hypertrophic and hypotrophic left ventricle of the obese and calorie-restricted mouse heart.Journal of anatomy · 2014Article
- Regenerative principles enrich cardiac rehabilitation practice.American journal of physical medicine & rehabilitation · 2014Review
- Translating stem cell research to cardiac disease therapies: pitfalls and prospects for improvement.Journal of the American College of Cardiology · 2014Review
Corrections and comments
- Retraction · 2014-04-08Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) ·
- Commented on by
- Retracted
Authors and funding
22 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTwo opposite views of cardiac growth are currently held; one views the heart as a static organ characterized by a large number of cardiomyocytes that are present at birth and live as long as the organism, and the other views the heart a highly plastic organ in which the myocyte compartment is restored several times during the course of life. METHODS AND
resultsThe average age of cardiomyocytes, vascular endothelial cells (ECs), and fibroblasts and their turnover rates were measured by retrospective (14)C birth dating of cells in 19 normal hearts 2 to 78 years of age and in 17 explanted failing hearts 22 to 70 years of age. We report that the human heart is characterized by a significant turnover of ventricular myocytes, ECs, and fibroblasts, physiologically and pathologically. Myocyte, EC, and fibroblast renewal is very high shortly after birth, decreases during postnatal maturation, remains relatively constant in the adult organ, and increases dramatically with age. From 20 to 78 years of age, the adult human heart entirely replaces its myocyte, EC, and fibroblast compartment ≈8, ≈6, and ≈8 times, respectively. Myocyte, EC, and fibroblast regeneration is further enhanced with chronic heart failure.
conclusionsThe human heart is a highly dynamic organ that retains a remarkable degree of plasticity throughout life and in the presence of chronic heart failure. However, the ability to regenerate cardiomyocytes, vascular ECs, and fibroblasts cannot prevent the manifestations of myocardial aging or oppose the negative effects of ischemic and idiopathic dilated cardiomyopathy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.