ArticleEuropean radiology2013
Grading of uterine cervical cancer by using the ADC difference value and its correlation with microvascular density and vascular endothelial growth factor.
Article in European radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic performance of diffusion-weighted MRI for detection of pelvic metastatic lymph nodes in patients with cervical cancer: a systematic review and meta-analysis.The British journal of radiology · 2015Pooled it
- Influence of virtual dynamic contrast enhanced breast MRI on lesion size, BI-RADS scores and reader confidence.European radiology · 2026Article
- Multi-model quantitative MRI of uterine cancers in precision medicine's era-a narrative review.Insights into imaging · 2025Article
- Evaluation of the diagnostic utility of MCAM-1 (CD146) in a group of common gynecological cancers: A case-control study.Turkish journal of obstetrics and gynecology · 2024Article
- A correlative study between IVIM-DWI parameters and VEGF and MMPs expression in hepatocellular carcinoma.Quantitative imaging in medicine and surgery · 2023Article
- Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models.Frontiers in medicine · 2023Article
- Intravoxel Incoherent Motion (IVIM) MR Quantification in Locally Advanced Cervical Cancer (LACC): Preliminary Study on Assessment of Tumor Aggressiveness and Response to Neoadjuvant Chemotherapy.Journal of personalized medicine · 2022Article
- Effects of Stellera chamaejasme on microvascular density and apoptosis of cancer cells in a rat bladder tumor model.Translational andrology and urology · 2022Article
- Post treatment imaging in patients with local advanced cervical carcinoma.Frontiers in oncology · 2022Review
- Cervical Carcinoma: Evaluation Using Diffusion MRI With a Fractional Order Calculus Model and its Correlation With Histopathologic Findings.Frontiers in oncology · 2022Article
- Whole-tumor texture model based on diffusion kurtosis imaging for assessing cervical cancer: a preliminary study.European radiology · 2021Article
- Application of Field-of-View Optimized and Constrained Undistorted Single Shot (FOCUS) with Intravoxel Incoherent Motion (IVIM) in 3T in Locally Advanced Rectal Cancer.Disease markers · 2021Article
- MRI texture features differentiate clinicopathological characteristics of cervical carcinoma.European radiology · 2020Article
- Texture Analysis of Apparent Diffusion Coefficient Maps in Cervical Carcinoma: Correlation with Histopathologic Findings and Prognosis.Radiology. Imaging cancer · 2020Article
- Histogram analysis of apparent diffusion coefficients for predicting pelvic lymph node metastasis in patients with uterine cervical cancer.Magma (New York, N.Y.) · 2020Article
- Association Between VEGF Expression and Diffusion Weighted Imaging in Several Tumors-A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2019Article
- Intravital assessment of angioarchitecture in rat hepatocellular nodules usingQuantitative imaging in medicine and surgery · 2019Article
- Whole-lesion ADC histogram analysis is not able to reflect microvessel density in HNSCC.Medicine · 2019Article
- Accurate IVIM model-based liver lesion characterisation can be achieved with only three b-value DWI.European radiology · 2018Article
- Tumor radiomic heterogeneity: Multiparametric functional imaging to characterize variability and predict response following cervical cancer radiation therapy.Journal of magnetic resonance imaging : JMRI · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the application value of the ADC(difference) value in evaluating the pathological grade of uterine cervical cancer and to analyse the correlations among microvascular density (MVD), vascular endothelial growth factor (VEGF) expression and maximum ADC(difference) value.
methodsFifty-six patients with uterine cervical cancer were included in this prospective study. All underwent conventional MRI and DWI. MVD and VEGF were evaluated by immunohistochemical staining with anti-CD34 and anti-VEGF, respectively.
resultsMaximum ADC(difference) value and MVD count showed statistical differences among different pathological grades (P < 0.001, P < 0.001). There was a significant positive linear correlation between the maximum ADC(difference) value and pathological tumour grade (P < 0.001), and also between MVD count and pathological tumour grade (P < 0.001). No significant differences were found between the level of VEGF expression and pathological tumour grade (P = 0.222). The maximum ADC(difference) value correlated positively with both the MVD count and the level of VEGF expression (P < 0.001, P < 0.001).
conclusionsQuantitative analysis of maximum ADC(difference) value of uterine cervical cancer may represent the grade of tumour differentiation and provide valuable information on tumour microcirculation and perfusion, thus allowing a promising new method of non-invasively assessing the pathological grade, which could serve as a substitution for assessing tumour angiogenesis.
Indexed as
Identifiers
22955960What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.