ArticleClinical and experimental medicine2013
Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.
Article in Clinical and experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Association ofInternational journal of fertility & sterility · 2023Pooled it
- Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Pooled it
- Genetic polymorphisms of IL17A associated with Chagas disease: results from a meta-analysis in Latin American populations.Scientific reports · 2020Pooled it
- Interleukin-17 SNPs and serum levels increase ulcerative colitis risk: a meta-analysis.World journal of gastroenterology · 2014Pooled it
- Characteristics of Japanese inflammatory bowel disease susceptibility loci.Journal of gastroenterology · 2014Pooled it
- Context-specific roles for IL-17 in tuberculosis.PLoS pathogens · 2026Review
- Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis.BMC gastroenterology · 2023Article
- The IL23-IL17 Immune Axis in the Treatment of Ulcerative Colitis: Successes, Defeats, and Ongoing Challenges.Frontiers in immunology · 2021Review
- IL12B and IL23R polymorphisms are associated with alopecia areata.Genes and immunity · 2020Article
- Association between rs2275913 single-nucleotide polymorphism of the interleukin-17A gene and perioperative analgesic use in cosmetic orthognathic surgery.Neuropsychopharmacology reports · 2018Article
- The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina.Scientific reports · 2017Article
- Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure.Medicine · 2016Article
- Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children.Rheumatology international · 2016Article
- Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Genetic Analysis of IL-17 Gene Polymorphisms in Gout in a Male Chinese Han Population.PloS one · 2016Article
- IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis.Archivum immunologiae et therapiae experimentalis · 2015Article
- Genetic variants of interleukin 17A are functionally associated with increased risk of age-related macular degeneration.Inflammation · 2015Article
- StIL-17 gene polymorphisms in the development of pulmonary tuberculosis.International journal of clinical and experimental pathology · 2015Article
- Fusobacterium detected in colonic biopsy and clinicopathological features of ulcerative colitis in Japan.Digestive diseases and sciences · 2015Article
- Role of IL-17 Variants in Preeclampsia in Chinese Han Women.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-17A plays a role in tissue inflammation by inducing release of proinflammatory and neutrophil-mobilizing cytokines. We investigated the association between ulcerative colitis (UC) and polymorphisms of IL17A, rs2275913 (-197 G > A), and rs3748067 (*1249 C > T). The study was performed in 475 healthy subjects (controls) and 202 with UC (UC cases), including 113 controls and 64 UC cases from previous study. We employed the multiplex PCR-SSCP method to detect gene polymorphisms. The minor allele frequency of rs2275913 was significantly higher but that of rs3748067 was significantly lower in UC cases than controls. The rs2275913 minor homozygote (AA) had an increased risk of the development of UC, whereas rs3748067 minor carrier (CT + TT) had decreased risks for the development of UC. When compared with LR group (rs2275913 GG + GA with rs3748067 CT + TT), HR group (rs2275913 AA with rs3748067 CC) had a more increased risk of the development of UC (OR, 3.38; p = 0.0007). The polymorphisms of IL17A were associated with the noncontinuous and pancolitis phenotypes of UC. Our results suggest that IL17A polymorphisms (both rs2275913 and rs3748067) influence the susceptibility to and pathophysiological features of UC, coordinately.
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