ArticleJournal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases2012
Relation of sensory peripheral neuropathy in Sjögren syndrome to anti-Ro/SSA.
Article in Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Recommendations on neurologic, cognitive, and psychiatric manifestations in patients with Sjögren's disease by the Brazilian Society of Rheumatology.Advances in rheumatology (London, England) · 2025Guideline
- Multicenter Analytical Comparison of Automated Quantitative Assays Versus Line Immunoassay for Anti-Ro/La Antibody Detection in Primary Sjögren's Syndrome.Journal of immunology research · 2026Article
- Clinical Profile of Patients with Primary Sjögren's Syndrome with Non-Identified Antinuclear Autoantibodies.Diagnostics (Basel, Switzerland) · 2024Article
- Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus.Lupus science & medicine · 2024Article
- Discordant Predictions of Extraglandular Involvement in Primary Sjögren's Syndrome According to the Anti-SSA/Ro60 Antibodies Detection Assay in a Cohort Study.Journal of clinical medicine · 2022Article
- Current state of technologies and recognition of anti-SSA/Ro antibodies in China: A multi-center study.Journal of clinical laboratory analysis · 2021Article
- Serum Biomarkers for the Diagnosis of Glaucoma.Diagnostics (Basel, Switzerland) · 2020Article
- Immune-mediated axonal dysfunction in seropositive and seronegative primary Sjögren's syndrome.Annals of clinical and translational neurology · 2020Article
- Neuro-Sjögren: Peripheral Neuropathy With Limb Weakness in Sjögren's Syndrome.Frontiers in immunology · 2019Article
- Prognostic value of Sjögren's syndrome autoantibodies.Journal of laboratory and precision medicine · 2018Article
- Neurological Complications of Sjögren's Syndrome: Diagnosis and Management.Current treatment options in rheumatology · 2017Article
- Review of autoantigens in Sjögren's syndrome: an update.Journal of inflammation research · 2017Review
- Muscarinic type 3 receptor autoantibodies are associated with anti-SSA/Ro autoantibodies in Sjögren's syndrome.Journal of immunological methods · 2016Article
- Autoantibodies in Sjögren's Syndrome.Rheumatic diseases clinics of North America · 2016Review
- Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.Clinical immunology (Orlando, Fla.) · 2016Article
- Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome.Arthritis research & therapy · 2013Article
- Serological Influences on Dry Eye: Insights from the Sjögren's International Collaborative Clinical Alliance.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundSjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease.
methodsEight-eight patients attending a dry eyes-dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B(12) levels were determined using an enzyme-linked microtiter plate assay.
resultsTwenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ(2) = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ(2) = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B(12) levels to neuropathy among these patients with Sjögren syndrome.
conclusionsSensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.
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