Evidence map›Paper›PMID 22954959›Full record

ArticleAnnals of epidemiology2012

The PhenX Toolkit pregnancy and birth collections.

Nedra S Whitehead, Jane A Hammond, Michelle A Williams, Wayne Huggins, Sonja Hoover, Carol M Hamilton, Erin M Ramos, Heather A Junkins, William R Harlan, Carol J Hogue and 1 more

Abstract read
In one paragraph

Article in Annals of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Research standardization tools: pregnancy measures in the PhenX Toolkit.American journal of obstetrics and gynecology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nedra S WhiteheadRTI International, San Francisco, CA, USA. nwhitehead@rti.org
Jane A Hammond
Michelle A Williams
Wayne Huggins
Sonja Hoover
Carol M Hamilton
Erin M Ramos
Heather A Junkins
William R Harlan
Carol J Hogue
PhenX Reproductive Health Working Group

Funding

Building Consensus for Standard Measures for Genome-Wide Association StudiesU01HG004597 · NHGRI · RESEARCH TRIANGLE INSTITUTE · PI HAMILTON, CAROL MARIE · 2007 to 2012
$11.1M
NHGRI NIH HHS U01 HG004597NHGRI NIH HHS U01 HG004597-01
6 · The paper itself

Abstract

purposePregnancy and childbirth are normal conditions, but complications and adverse outcomes are common. Both genetic and environmental factors influence the course of pregnancy. Genetic epidemiologic research into pregnancy outcomes could be strengthened by the use of common measures, which would allow data from different studies to be combined or compared. Here, we introduce perinatal researchers to the PhenX Toolkit and the Collections related to pregnancy and childbirth.

methodsThe Pregnancy and Birth Collections were drawn from measures in the PhenX Tooklit. The lead author selected a list of measures for each Collection, which was reviewed by the remaining authors and revised on the basis of their comments. We chose the measures we thought were most relevant for perinatal research and had been linked most strongly to perinatal outcomes.

resultsThe Pregnancy and Birth Health Conditions Collection includes 24 measures related to pregnancy and fertility history, maternal complications, and infant complications. The Pregnancy and Birth Outcome Risk Factors Collection includes 43 measures of chemical, medical, psychosocial, and personal factors associated with pregnancy outcomes.

conclusionsThe biological complexity of pregnancy and its sensitivity to environmental and genomic influences suggest that multidisciplinary approaches are needed to generate new insights or practical interventions. To fully exploit new research methods and resources, we encourage the biomedical research community to adopt standard measures to facilitate pooled or meta-analyses.

Indexed as

Biomedical ResearchData CollectionFemaleHuman Genome ProjectHumansInfantPerinatal CarePhenotypePregnancyPregnancy OutcomeRisk Factors

Identifiers

PMID22954959
PMCPMC4508122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.