Evidence map›Paper›PMID 22954895›Full record

ReviewMolecular and cellular neurosciences2013

Mouse models of Parkinson's disease associated with mitochondrial dysfunction.

Alicia M Pickrell, Milena Pinto, Carlos T Moraes

Abstract readReview
In one paragraph

Review in Molecular and cellular neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Experimental Intrastriatal Applications of Botulinum Neurotoxin-A: A Review.International journal of molecular sciences · 2018
    Review
  6. Review
  7. Article
  8. Mitochondrial DNA damage induced autophagy, cell death, and disease.Frontiers in bioscience (Landmark edition) · 2016
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alicia M PickrellNeuroscience Graduate Program, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Milena Pinto
Carlos T Moraes

Funding

SETTING THE STAGE FOR REPLACEMENT OF MITOCHONDRIAL GENESR01EY010804 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 1995 to 2025
$9.4M
Cellular and Molecular Consequences of Respiratory Chain Defects in NeuronsR01NS079965 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 2012 to 2023
$3.9M
Mitochondrial Dysfunction in Neurodegeneration and Compensatory ApproachesR01AG036871 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 2010 to 2020
$3.3M
Mouse Models with Defective Respiratory Complexes in CNSR01NS041777 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 2001 to 2009
$2.4M
PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCEST32NS007492 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BIXBY, JOHN L · 2001 to 2010
$1.8M
TRAINING PROGRAM IN CNS INJURY AND REPAIRT32NS007459 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DIETRICH, W DALTON · 2000 to 2009
$1.7M
Mouse Models of Mitochondrial EncephalomyopathiesR56NS041777 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MORAES, CARLOS TORRES · 2010 to 2010
$445k
NEI NIH HHS EY010804NEI NIH HHS R01 EY010804NIA NIH HHS AG036871NIA NIH HHS R01 AG036871NINDS NIH HHS 5T32NS007459NINDS NIH HHS 5T32NS007492NINDS NIH HHS NS041777NINDS NIH HHS R01 NS041777NINDS NIH HHS R01 NS079965NINDS NIH HHS R56 NS041777NINDS NIH HHS T32 NS007459NINDS NIH HHS T32 NS007492
6 · The paper itself

Abstract

Despite years of intensive research, the understanding of Parkinson's disease (PD) is still rudimentary. Genetic causes of rare familial cases have offered venues of investigation, and interestingly, have strengthened the case for a mitochondrial dysfunction in the pathogenesis of PD. Mouse models, where these and other mitochondrial-related genes are affected are helping not only in understanding PD, but also in providing a powerful tool to test therapeutics. In this review, we will discuss the different characteristics of these mouse models. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.

Indexed as

Disease Models, AnimalMice, TransgenicAnimalsGenes, MitochondrialHumansMiceMitochondriaMitochondrial DynamicsMutationNeuronsParkinson Disease

Identifiers

PMID22954895
PMCPMC3997253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.