Evidence map›Paper›PMID 22954273›Full record

ReviewClinics in perinatology2012

Can nitric oxide-based therapy prevent bronchopulmonary dysplasia?

Thomas M Raffay, Richard J Martin, James D Reynolds

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. L-Citrulline in Neonates: From Bench to Bed Side.Children (Basel, Switzerland) · 2024
    Review
  3. Exogenous hydrogen sulfide attenuates hyperoxia effects on neonatal mouse airways.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas M RaffayDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Medical Center/University Hospitals, 11100 Euclid Avenue, Cleveland, OH 44106-6010, USA.
Richard J Martin
James D Reynolds

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Case Western Reserve University/Cleveland Clinic CTSA (KL2)KL2RR024990 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$9.5M
Red Blood Cell S-nitrosothiols and OxygenationR01HL091876 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2009 to 2012
$1.6M
Restoration and Function of S-nitrosothiol in Stored BloodR01HL095463 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STAMLER, JONATHAN S. · 2009 to 2012
$1.5M
NCRR NIH HHS KL2 RR024990NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1RR024989NHLBI NIH HHS HL 56470NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL091876NHLBI NIH HHS R01HL091876NHLBI NIH HHS R01 HL095463NHLBI NIH HHS R01HL095463
6 · The paper itself

Abstract

A growing understanding of endogenous nitric oxide (NO) biology is helping to explain how and when exogenous NO may confer benefit or harm; this knowledge is also helping to identify new better-targeted NO-based therapies. In this review, results of the bronchopulmonary dysplasia clinical trials that used inhaled NO in the preterm population are placed in context, the biologic basis for novel NO therapeutics is considered, and possible future directions for NO-focused clinical and basic research in developmental lung disease are identified.

Indexed as

Infant, PrematureAdministration, InhalationAnimalsBronchopulmonary DysplasiaHumansInfant, NewbornNitric OxidePractice Guidelines as TopicNitric Oxide

Identifiers

PMID22954273
PMCPMC3437658

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.