ArticleAnnals of the New York Academy of Sciences2012
Three-dimensional architecture of the IgH locus facilitates class switch recombination.
Article in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Review
- Review
- Three-dimensional genome rewiring during the development of antibody-secreting cells.Biochemical Society transactions · 2020Review
- New insights emerge as antibody repertoire diversification meets chromosome conformation.F1000Research · 2019Review
- TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination.F1000Research · 2018Review
- Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.Molecular immunology · 2016Article
- Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.The Journal of experimental medicine · 2016Article
- Cyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.Microbiology spectrum · 2015Review
- Genome-wide map of regulatory interactions in the human genome.Genome research · 2014Article
- IgH chain class switch recombination: mechanism and regulation.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Advances in immunology · 2014Review
- The cohesin complex regulates immunoglobulin class switch recombination.The Journal of experimental medicine · 2013Article
- Allelic exclusion of the immunoglobulin heavy chain locus is independent of its nuclear localization in mature B cells.Nucleic acids research · 2013Article
- G4 motifs in human genes.Annals of the New York Academy of Sciences · 2012Article
- Genome hyperevolution and the success of a parasite.Annals of the New York Academy of Sciences · 2012Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Immunoglobulin (Ig) class switch recombination (CSR) is responsible for diversification of antibody effector function during an immune response. This region-specific recombination event, between repetitive switch (S) DNA elements, is unique to B lymphocytes and is induced by activationinduced deaminase (AID). CSR is critically dependent on transcription of noncoding RNAs across S regions. However, mechanistic insight regarding this process has remained unclear. New studies indicate that long-range intrachromosomal interactions among IgH transcriptional elements organize the formation of the S/S synaptosome, as a prerequisite for CSR. This three-dimensional chromatin architecture simultaneously brings promoters and enhancers into close proximity to facilitate transcription. Here, we recount how transcription across S DNA promotes accumulation of RNA polymerase II, leading to the introduction of activating chromatin modifications and hyperaccessible chromatin that is amenable to AID activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.