ArticleAnnals of the New York Academy of Sciences2012
G4 motifs in human genes.
Article in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- CGGBP1-Regulated Heterogeneous C-T Transition Rates Correlate with G-quadruplex Potential of Terrestrial Vertebrate Genomes.Journal of molecular evolution · 2026Article
- Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription.Oncogene · 2026Article
- Differential Gene Expression followingInternational journal of molecular sciences · 2024Article
- G-quadruplexes in MTOR and induction of autophagy.Scientific reports · 2024Article
- Impact of G-Quadruplex Structures on Methylation of Model Substrates by DNA Methyltransferase Dnmt3a.International journal of molecular sciences · 2022Article
- On the Road to Fight Cancer: The Potential of G-quadruplex Ligands as Novel Therapeutic Agents.International journal of molecular sciences · 2021Review
- Characterization of long G4-rich enhancer-associated genomic regions engaging in a novel loop:loop 'G4 Kissing' interaction.Nucleic acids research · 2020Article
- Guanine Quadruplex DNA Regulates Gamma Radiation Response of Genome Functions in the Radioresistant BacteriumJournal of bacteriology · 2019Article
- G4HunterApps.Bioinformatics (Oxford, England) · 2019Article
- Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding.Molecules (Basel, Switzerland) · 2018Article
- BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes.Nature communications · 2018Article
- Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance.Nucleic acids research · 2016Article
- Article
- Targeting C-myc G-quadruplex: dual recognition by aminosugar-bisbenzimidazoles with varying linker lengths.Molecules (Basel, Switzerland) · 2013Article
- G-quadruplex structures in the human genome as novel therapeutic targets.Molecules (Basel, Switzerland) · 2013Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The G4 motif, G(≥3) N(x) G(≥3) N(x) G(≥3) N(x) G(≥3) , is enriched in some genomic regions and depleted in others. This motif confers the ability to form an unusual four-stranded DNA structure, G4 DNA. G4 DNA is associated with genomic instability, which may explain depletion of G4 motifs from some genes and genomic regions. Conversely, G4 motifs are enriched downstream of transcription start sites, where they correlate with pausing. The uneven distribution of G4 motifs in the genome strongly suggests that mechanisms of selection act not only on one-dimensional genomic sequence, but also on structures formed by genomic DNA. The biological roles of G4 structures illustrate that, to understand genome function, it is important to consider the dynamic structural potential implicit in the G4 motif.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.